No paralogue variants have been mapped to residue 1644 for CACNA1C.
| CACNA1C | ATFLIQEYF-RKFKKRKE--QGLV-GK--P>S<--------QRNALS-L-QAGLRTL-H-DIG | 1662 |
| CACNA1A | AAMMIMEYY-RQSKAKK--LQAMR-E---E>Q<DRTPLMFQRMEPPS------PTQ------- | 1998 |
| CACNA1B | AALMIFDFY-KQNKTTRDQMQQAPGG---L>S<----QMGPVSLFHP------LKATLE-QT- | 1901 |
| CACNA1D | ATFLIQDYF-RKFKKRKE--QGLV-GK-YP>A<--------KNTTIA-L-QAGLRTL-H-DIG | 1671 |
| CACNA1E | AAMMIMDYY-KQSKVKKQ--RQQL-E---E>Q<-KNAPMFQRMEPSS------LPQ------- | 1909 |
| CACNA1F | ATFLIQDYF-RKFRRRKE--KGLL-GN-DA>A<--------PSTSSA-L-QAGLRSL-Q-DLG | 1628 |
| CACNA1G | IPLAEMEAL-SLTSEIVS--EPSC------>-<-----------SLA------LTD------- | 2002 |
| CACNA1H | LQEVEMETYGAGTPLGSV--ASVH-SP-PA>E<-SCASLQIPLAVSS------PAR------- | 1990 |
| CACNA1I | VQLAETEAF-SLNSDRSS--SILL-GD-DL>S<-LEDPTACPPGRKD------SKG------- | 1889 |
| CACNA1S | ATFLIQEHF-RKFMKRQE--EYY--GY--R>P<--------KKDIVQ-I-QAGLRTI-EEEAA | 1567 |
| SCN10A | -ATVIQKAY-RSYVLHRS--MALS-NTPCV>P<---------RAEEE---AASLPDEGF-VAF | 1897 |
| SCN11A | -AAIIQKAF-RKYMMKVT--KGDQ-G-D-->Q<-----------------------NDL---- | 1762 |
| SCN1A | -AVIIQRAY-RRHLLKRT--VKQA-SFTYN>K<---------NKIKG--GANLLIKEDM-IID | 1962 |
| SCN2A | -AIIIQRAY-RRYLLKQK--VKKV-SSIYK>K<---------DKGKE--CDGTPIKEDT-LID | 1952 |
| SCN3A | -AAIIQRNF-RCYLLKQR--LKNI-SSNYN>K<---------EAIKG--RIDLPIKQDM-IID | 1947 |
| SCN4A | -AIKIQRAY-RRHLLQRS--MKQA-SYMYR>H<---------SHDGS--GDDAPEKEGL-LAN | 1774 |
| SCN5A | -AMVIQRAF-RRHLLQRS--LKHA-SFLFR>Q<---------QAGSGLSEEDAPEREGL-IAY | 1950 |
| SCN7A | -ATIIQRAY-KNYRLRRN--DKNT-SDIHM>I<---------DGDR----DVHATKEGA-YFD | 1670 |
| SCN8A | -AVVLQRAY-RGHLARRG--FIC------->-<----------------------KKTT-SNK | 1924 |
| SCN9A | -ATVIQRAY-RRYRLRQN--VKNI-SSIYI>K<---------DGDRD---DDLLNKKDM-AFD | 1924 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.S1644F | c.4931C>T | Putative Benign | rs376642156 | SIFT: deleterious Polyphen: possibly damaging |