No paralogue variants have been mapped to residue 1649 for CACNA1C.
| CACNA1C | KKRKE--QGLV-GK--PS--------QRNA>L<S-L-QAGLRTL-H-DIGPE-IRRA------ | 1668 |
| CACNA1A | KAKK--LQAMR-E---EQDRTPLMFQRMEP>P<S------PTQ-------EG-GP-G------ | 2003 |
| CACNA1B | KTTRDQMQQAPGG---LS----QMGPVSLF>H<P------LKATLE-QT-QPAVLRGARVFLR | 1914 |
| CACNA1D | KKRKE--QGLV-GK-YPA--------KNTT>I<A-L-QAGLRTL-H-DIGPE-IRRA------ | 1677 |
| CACNA1E | KVKKQ--RQQL-E---EQ-KNAPMFQRMEP>S<S------LPQ-------EI-IA-N------ | 1914 |
| CACNA1F | RRRKE--KGLL-GN-DAA--------PSTS>S<A-L-QAGLRSL-Q-DLGPE-MRQA------ | 1634 |
| CACNA1G | SEIVS--EPSC------------------S>L<A------LTD-------DSLP--------D | 2007 |
| CACNA1H | PLGSV--ASVH-SP-PAE-SCASLQIPLAV>S<S------PAR-------SGEPLHALSPRGT | 2003 |
| CACNA1I | SDRSS--SILL-GD-DLS-LEDPTACPPGR>K<D------SKG-------ELDP-----PEPM | 1897 |
| CACNA1S | MKRQE--EYY--GY--RP--------KKDI>V<Q-I-QAGLRTI-EEEAAPE-ICRT------ | 1573 |
| SCN10A | VLHRS--MALS-NTPCVP---------RAE>E<E---AASLPDEGF-VAFTA----------- | 1899 |
| SCN11A | MMKVT--KGDQ-G-D--Q------------>-<----------NDL-----E----------- | 1763 |
| SCN1A | LLKRT--VKQA-SFTYNK---------NKI>K<G--GANLLIKEDM-IIDRI----------- | 1964 |
| SCN2A | LLKQK--VKKV-SSIYKK---------DKG>K<E--CDGTPIKEDT-LIDKL----------- | 1954 |
| SCN3A | LLKQR--LKNI-SSNYNK---------EAI>K<G--RIDLPIKQDM-IIDKL----------- | 1949 |
| SCN4A | LLQRS--MKQA-SYMYRH---------SHD>G<S--GDDAPEKEGL-LANTM-SKMY------ | 1780 |
| SCN5A | LLQRS--LKHA-SFLFRQ---------QAG>S<GLSEEDAPEREGL-IAYVM----------- | 1952 |
| SCN7A | RLRRN--DKNT-SDIHMI---------DGD>R<----DVHATKEGA-YFDKA----------- | 1672 |
| SCN8A | LARRG--FIC-------------------->-<---------KKTT-SNKLE----------- | 1926 |
| SCN9A | RLRQN--VKNI-SSIYIK---------DGD>R<D---DDLLNKKDM-AFDNV----------- | 1926 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.L1649P | c.4946T>C | Putative Benign | SIFT: Polyphen: | ||
| p.L1649V | c.4945C>G | Putative Benign | SIFT: tolerated Polyphen: probably damaging |