No paralogue variants have been mapped to residue 1721 for CACNA1C.
| CACNA1C | GGLFGNHV-SYYQSDG--------RSAFPQ>T<FT---T-------QRPLHINKAGSS-QGDT | 1740 |
| CACNA1A | MREMGRDG-YSDSEHYLPMEGQGRAASMPR>L<PA---------------------------- | 2099 |
| CACNA1B | VQMQSITRRGPDGEPQPGLESQGRAASMPR>L<AA---------------------------- | 2008 |
| CACNA1D | GALLGNHV-NHVNSDR--------RDSLQQ>T<NT---T-------HRPLHVQRPSIPPASDT | 1744 |
| CACNA1E | SVQPSNHG-IYLPSDTQEHAGSGRASSMPR>L<TV---------------------------- | 2006 |
| CACNA1F | ATMVSQPS-AR---RG--------SGISVS>L<PVGDRL-------PDSLSFG---P------ | 1695 |
| CACNA1G | KA--------------Q----SGSVLSVHS>Q<P-----------ADT-----------SYIL | 2093 |
| CACNA1H | T--------------RK----HTFGQRCVS>S<RP---AAP----GGE-----------EAEA | 2093 |
| CACNA1I | HPAVSASQ-KGPEKGTG----TGTLPKIAL>Q<GS---WASLRSPRVN-----------CTLL | 2007 |
| CACNA1S | GGLFGQVD-NFL--ER--------TNSLPP>V<MA---N-------QRPLQFAEIE---MEEM | 1638 |
| SCN10A | KS---------------------------->-<------------------------------ | 1909 |
| SCN11A | QT---------------------------->-<------------------------------ | 1772 |
| SCN1A | KT---------------------------->-<------------------------------ | 1973 |
| SCN2A | KT---------------------------->-<------------------------------ | 1963 |
| SCN3A | KT---------------------------->-<------------------------------ | 1958 |
| SCN4A | PE---------------------------->-<------------------------------ | 1793 |
| SCN5A | SS---------------------------->-<------------------------------ | 1965 |
| SCN7A | ------------------------------>-<------------------------------ | |
| SCN8A | KK---------------------------->-<------------------------------ | 1935 |
| SCN9A | KT---------------------------->-<------------------------------ | 1935 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.T1721S | c.5162C>G | Putative Benign | SIFT: tolerated Polyphen: benign |