Paralogue Annotation for CACNA1C residue 1859

Residue details

Gene: CACNA1C
Reference Sequences: LRG: LRG_334, Ensembl variant: ENST00000399655 / ENSP00000382563
Amino Acid Position: 1859
Reference Amino Acid: L - Leucine
Protein Domain: C-terminus


Paralogue Variants mapped to CACNA1C residue 1859

No paralogue variants have been mapped to residue 1859 for CACNA1C.



CACNA1CETYEVKMNHDTEACSEPSLLSTE------M>L<SYQDDENRQL--------TLPEEDKRDIRQ1881
CACNA1APPEENQRHHQ--R---RRDRSHRASERSLG>R<YTDV---DTGL---------------GTDL2182
CACNA1BPPSQASSHHHHHRCHRRRDRKQRSLEKGPS>L<SADM---DGAP---------------SSAV2086
CACNA1DEYFSSEECYEDDSSPTWSRQNYGYYSRYPG>R<NIDSERPRGYHHPQGFLEDDDSPVCYDSRR1924
CACNA1ESMERSSENTY--K---SRRRSYHSSLRLSA>H<RLNS---DSGH---------------KSDT2075
CACNA1FEEVPDRLSYLDEQAGTPP-CSVL------->-<--------LP--------PHRAQRYMDGHL1785
CACNA1GRAYSFWGQSS--T---Q------------->-<-------AQQ--------HSR------SHS2185
CACNA1H------------------------------>-<------------------------------
CACNA1I------------------------------>-<------------------------------
CACNA1S----ANVAYGNSNHSNSHVFSSVHYEREFP>E<ETET------------------------PA1698
SCN10A------------------------------>-<------------------------------
SCN11A------------------------------>-<------------------------------
SCN1A------------------------------>-<------------------------------
SCN2A------------------------------>-<------------------------------
SCN3A------------------------------>-<------------------------------
SCN4A------------------------------>-<------------------------------
SCN5A------------------------------>-<------------------------------
SCN7A------------------------------>-<------------------------------
SCN8A------------------------------>-<------------------------------
SCN9A------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in CACNA1C

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.L1859Pc.5576T>C Putative BenignSIFT: tolerated
Polyphen: possibly damaging