Paralogue Annotation for CACNA1C residue 2113

Residue details

Gene: CACNA1C
Reference Sequences: LRG: LRG_334, Ensembl variant: ENST00000399655 / ENSP00000382563
Amino Acid Position: 2113
Reference Amino Acid: D - Aspartate
Protein Domain: C-terminus


Paralogue Variants mapped to CACNA1C residue 2113

No paralogue variants have been mapped to residue 2113 for CACNA1C.



CACNA1CAPQSPNGALLPFVNCRDAG---QDRAGGEE>D<A----------GCV-----RARGRPSEEEL2128
CACNA1A------------------------------>-<--------------------------RSPS2251
CACNA1BGRSSRTSYVSSLTSQSHPL---RRVPNGYH>C<TLG-LS--------------SGGR--ARHS2330
CACNA1DVRPRANGDVGPLSHRQDYE---LQDFGPGY>S<D----------E-E-----PDPGR-DEEDL2171
CACNA1EGRSNTIGSAPPLRHSW-------QMPNGHY>R<RRR-RG-----GPG-----PGMMCGAVNNL2303
CACNA1FTSS-------------------------LY>S<D----------E-E-----SILSRFDEEDL1967
CACNA1GPKKDVLSLSGLSSDPADLD----------->-<------------------------------2376
CACNA1HVTPESRASSSGAIVPLEPPESEPPMPVGDP>P<EKRRGLYLTVPQ-CPLEKPGSPSA--TPA-2344
CACNA1IRSPSWAADRSKDPPGRAPLPMGLGPLAPP->-<------------------PQPLPG--ELE-2213
CACNA1SEAPEGMASSLGCLNL--------------->-<-------------G-----SSLGSLDQHQG1863
SCN10A------------------------------>-<------------------------------
SCN11A------------------------------>-<------------------------------
SCN1A------------------------------>-<------------------------------
SCN2A------------------------------>-<------------------------------
SCN3A------------------------------>-<------------------------------
SCN4A------------------------------>-<------------------------------
SCN5A------------------------------>-<--------------------------DFPP2006
SCN7A------------------------------>-<------------------------------
SCN8A------------------------------>-<------------------------------
SCN9A------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in CACNA1C

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.D2113Nc.6337G>A Putative BenignSIFT: tolerated
Polyphen: benign