No paralogue variants have been mapped to residue 219 for CACNA1C.
| CACNA1C | YLRNGWNLLDFIIVVVGLFSAILEQATKA->D<GANALGGKGAGFDVKALRAFRVLRPLRLVS | 249 |
| CACNA1A | YLRNGWNVMDFVVVLTGILATVGTEF---->-<------------DLRTLRAVRVLRPLKLVS | 207 |
| CACNA1B | YLRNGWNVMDFVVVLTGILATAGTDF---->-<------------DLRTLRAVRVLRPLKLVS | 204 |
| CACNA1D | YVRNGWNLLDFVIVIVGLFSVILEQLTKET>E<GGNHSSGKSGGFDVKALRAFRVLRPLRLVS | 252 |
| CACNA1E | YLRNGWNVMDFIVVLSGILATAGTHFN--->-<---------THVDLRTLRAVRVLRPLKLVS | 202 |
| CACNA1F | YIRNGWNLLDFIIVVVGLFSVLLEQGPGRP>G<DAPHTGGKPGGFDVKALRAFRVLRPLRLVS | 218 |
| CACNA1G | YLGDTWNRLDFFIVIAGMLEYSLDLQ---->-<----------NVSFSAVRTVRVLRPLRAIN | 192 |
| CACNA1H | YLGDTWNRLDFFIVVAGMMEYSLDGH---->-<----------NVSLSAIRTVRVLRPLRAIN | 211 |
| CACNA1I | YLGDTWNRLDFFIVMAGMVEYSLDLQ---->-<----------NINLSAIRTVRVLRPLKAIN | 190 |
| CACNA1S | YLRSGWNVLDFTIVFLGVFTVILEQVNVIQ>S<HTAPMSSKGAGLDVKALRAFRVLRPLRLVS | 177 |
| SCN10A | YLRDPWNWLDFSVITLAYVGTAIDLR---->-<------------GISGLRTFRVLRALKTVS | 227 |
| SCN11A | FLRDPWNWLDSIVIGIAIVSYIPGIT---->-<-----------IKLLPLRTFRVFRALKAIS | 234 |
| SCN1A | FLRDPWNWLDFTVITFAYVTEFVDLG---->-<------------NVSALRTFRVLRALKTIS | 228 |
| SCN2A | FLRDPWNWLDFTVITFAYVTEFVDLG---->-<------------NVSALRTFRVLRALKTIS | 229 |
| SCN3A | FLRDPWNWLDFSVIVMAYVTEFVDLG---->-<------------NVSALRTFRVLRALKTIS | 228 |
| SCN4A | FLRDPWNWLDFSVIMMAYLTEFVDLG---->-<------------NISALRTFRVLRALKTIT | 231 |
| SCN5A | FLRDPWNWLDFSVIIMAYVSENIKLG---->-<------------NLSALRTFRVLRALKTIS | 231 |
| SCN7A | FLGDPWNWLDFSVTVFEVIIRYSPLD---->-<------------FIPTLQTARTLRILKIIP | 218 |
| SCN8A | FLRDPWNWLDFSVIMMAYITEFVNLG---->-<------------NVSALRTFRVLRALKTIS | 232 |
| SCN9A | FLRDPWNWLDFVVIVFAYLTEFVNLG---->-<------------NVSALRTFRVLRALKTIS | 226 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.D219E | c.657T>A | Putative Benign | SIFT: Polyphen: |