No paralogue variants have been mapped to residue 222 for CACNA1C.
| CACNA1C | NGWNLLDFIIVVVGLFSAILEQATKA-DGA>N<ALGGKGAGFDVKALRAFRVLRPLRLVSGVP | 252 |
| CACNA1A | NGWNVMDFVVVLTGILATVGTEF------->-<---------DLRTLRAVRVLRPLKLVSGIP | 210 |
| CACNA1B | NGWNVMDFVVVLTGILATAGTDF------->-<---------DLRTLRAVRVLRPLKLVSGIP | 207 |
| CACNA1D | NGWNLLDFVIVIVGLFSVILEQLTKETEGG>N<HSSGKSGGFDVKALRAFRVLRPLRLVSGVP | 255 |
| CACNA1E | NGWNVMDFIVVLSGILATAGTHFN------>-<------THVDLRTLRAVRVLRPLKLVSGIP | 205 |
| CACNA1F | NGWNLLDFIIVVVGLFSVLLEQGPGRPGDA>P<HTGGKPGGFDVKALRAFRVLRPLRLVSGVP | 221 |
| CACNA1G | DTWNRLDFFIVIAGMLEYSLDLQ------->-<-------NVSFSAVRTVRVLRPLRAINRVP | 195 |
| CACNA1H | DTWNRLDFFIVVAGMMEYSLDGH------->-<-------NVSLSAIRTVRVLRPLRAINRVP | 214 |
| CACNA1I | DTWNRLDFFIVMAGMVEYSLDLQ------->-<-------NINLSAIRTVRVLRPLKAINRVP | 193 |
| CACNA1S | SGWNVLDFTIVFLGVFTVILEQVNVIQSHT>A<PMSSKGAGLDVKALRAFRVLRPLRLVSGVP | 180 |
| SCN10A | DPWNWLDFSVITLAYVGTAIDLR------->-<---------GISGLRTFRVLRALKTVSVIP | 230 |
| SCN11A | DPWNWLDSIVIGIAIVSYIPGIT------->-<--------IKLLPLRTFRVFRALKAISVVS | 237 |
| SCN1A | DPWNWLDFTVITFAYVTEFVDLG------->-<---------NVSALRTFRVLRALKTISVIP | 231 |
| SCN2A | DPWNWLDFTVITFAYVTEFVDLG------->-<---------NVSALRTFRVLRALKTISVIP | 232 |
| SCN3A | DPWNWLDFSVIVMAYVTEFVDLG------->-<---------NVSALRTFRVLRALKTISVIP | 231 |
| SCN4A | DPWNWLDFSVIMMAYLTEFVDLG------->-<---------NISALRTFRVLRALKTITVIP | 234 |
| SCN5A | DPWNWLDFSVIIMAYVSENIKLG------->-<---------NLSALRTFRVLRALKTISVIP | 234 |
| SCN7A | DPWNWLDFSVTVFEVIIRYSPLD------->-<---------FIPTLQTARTLRILKIIPLNQ | 221 |
| SCN8A | DPWNWLDFSVIMMAYITEFVNLG------->-<---------NVSALRTFRVLRALKTISVIP | 235 |
| SCN9A | DPWNWLDFVVIVFAYLTEFVNLG------->-<---------NVSALRTFRVLRALKTISVIP | 229 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.N222D | c.664A>G | Putative Benign | rs373085638 | SIFT: tolerated Polyphen: benign |