No paralogue variants have been mapped to residue 461 for CACNA1C.
| CACNA1C | ---------------------------EEK>P<R------N--MSM---P-----T-----SE | 470 |
| CACNA1A | ------------------------PFDG-A>L<R------R--TTI---K-K---------SK | 430 |
| CACNA1B | ------------------------PLDA-V>L<K------R--AAT---K-K---------SR | 426 |
| CACNA1D | ---------------------------E-G>K<R------N--TSM---P-----T-----SE | 470 |
| CACNA1E | ------------------------L--E-V>L<R------R--ATI---K-R---------SR | 419 |
| CACNA1F | ---------------------------E-G>-<RAGHRPQL--AEL---T-NRRRGRLRWFSH | 456 |
| CACNA1G | -HHHHHHHHYHL-GNGTLRAPRASPEIQ-D>R<D------ANGSRRLMLP-P---------PS | 538 |
| CACNA1H | -HHHHHHHHYHF-SHGSPRRPGPEPGAC-D>T<R------LVR-----AG-A---------PP | 557 |
| CACNA1I | -GRHLGSRHCQT-LHGP------------->-<-----------------------------A | 513 |
| CACNA1S | ------------------------------>-<-------S--LDE---G-----G-----SD | 394 |
| SCN10A | ---------RRMSFLGLASGKRRASHG--S>V<F------H--FRS---PGR-DIS-----LP | 517 |
| SCN11A | ------------------------------>-<------------------------------ | |
| SCN1A | EKRYSSPHQSLLSIRGSLFSPRRNSRT--S>L<F------S--FRG---RAK-DVG-----SE | 587 |
| SCN2A | EKRFSSPHQSLLSIRGSLFSPRRNSRA--S>L<F------S--FRG---RAK-DIG-----SE | 590 |
| SCN3A | DKKFCSPHQSLLSIRGSLFSPRRNSKT--S>I<F------S--FRG---RAK-DVG-----SE | 590 |
| SCN4A | ------------------------------>-<------------------------------ | |
| SCN5A | -------HLSLTRGLSRTSMKPRSSRG--S>I<F------T--FRR-----R-DLG-----SE | 540 |
| SCN7A | ------------------------------>-<------------------------------ | |
| SCN8A | -RKFSIMNQSLLSIPGSPFLSRHNSKS--S>I<F------S--FRGPG-RFR-DPG-----SE | 580 |
| SCN9A | EKRLSTPNQSPLSIRGSLFSARRSSRT--S>L<F------S--FKG---RGR-DIG-----SE | 567 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.P461T | c.1381C>A | Putative Benign | SIFT: Polyphen: |