No paralogue variants have been mapped to residue 486 for CACNA1C.
| CACNA1C | E----------SVNTENVAG-G-D----IE>G<EN-CG------------------------- | 490 |
| CACNA1A | D----------LLNPEEAED-QLA----DI>A<-S-VG------------------------- | 450 |
| CACNA1B | D----------LIHAEEGED-RFA----DL>C<-A-VG------------------------- | 446 |
| CACNA1D | E----------SVNTENVSG-EGE----NR>G<-C-CGSLWCWWR-------RRGA-AKA--- | 504 |
| CACNA1E | E----------AMTRDSSDE-HCV----DI>S<-S-VG------------------------- | 439 |
| CACNA1F | T----------RS-THSTSSHASL----P->A<-SDTGSMTETQG-------DEDE-EEG--- | 490 |
| CACNA1G | K----------ADSGACGPD-SCP----YC>A<-R-AG-----AG-----EVELADREMP-DS | 688 |
| CACNA1H | P----------AGTLTCELK-SCP----YC>T<-R-AL-----ED-P---EGELSGSESG-DS | 722 |
| CACNA1I | -----------------DPA-SCP----CC>Q<-H-ED-----GR-RPSGLGS---TDSGQEG | 576 |
| CACNA1S | E----------SLY-EI------------->-<-------------------------AG--- | 403 |
| SCN10A | DVSAFD---AGQKKTFLSAE-YLDEPFRAQ>R<-A-MSVVSIITSV----L-EELE-ESE--- | 628 |
| SCN11A | -------KRLSQNLSLDHFD-EHGDPLQRQ>R<-A-LSAVSILTIT----M-KEQE-KSQ--- | 540 |
| SCN1A | TTTETEMRKRRSSSFHVSMD-FLEDPSQRQ>R<-A-MSIASILTNT----V-EELE-ESR--- | 731 |
| SCN2A | TTTETEIRKRRSSSYHVSMD-LLEDPTSRQ>R<-A-MSIASILTNT----M-EELE-ESR--- | 722 |
| SCN3A | TTTETEVRKRRLSSYQISME-MLEDSSGRQ>R<-A-VSIASILTNT----M-EELE-ESR--- | 723 |
| SCN4A | ---------------------E---KGAPR>Q<-S-SSGDSGISDA----M-EELE-EAH--- | 541 |
| SCN5A | TPSEEPGGPQMLTSQAPCVD-GFEEPGARQ>R<-A-LSAVSVLTSA----L-EELE-ESR--- | 680 |
| SCN7A | -TIQIEMKKRSPISTDTSLD-VLEDATLRH>K<-------------------EELE-KSK--- | 468 |
| SCN8A | -TTEVEIKKKGPGSLLVSMD-QLASYGRKD>R<-I-NSIMSVVTNTL---V-EELE-ESQ--- | 716 |
| SCN9A | TTNQIH-KKRRCSSYLLSED-MLNDPNLRQ>R<-A-MSRASILTNT----V-EELE-ESR--- | 696 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.G486R | c.1456G>A | Putative Benign | SIFT: Polyphen: |