No paralogue variants have been mapped to residue 1059 for KCNH2.
| KCNH2 | PGRRPRGDV-ESRLDALQRQLNRLETRLSA>D<MATVLQ--------------LLQRQMTLVP | 1075 |
| KCNH1 | -----RTKA-S-----GEATLKKTDSCDSG>I<TKSDLR--------------LDNVGEARSP | 900 |
| KCNH3 | ---LLTVPH-GPSEARNTDTLDKLRQAVTE>L<SEQVLQ--------------MREGLQSLRQ | 904 |
| KCNH4 | RP-SPELAS-EAEEVK--EKVCRLNQEISR>L<NQEVSQ--------------LSRELRHIMG | 906 |
| KCNH5 | PKSSDSENS-V-----TKNPLRKTDSCDSG>I<TKSDLR--------------LDKAGEARSP | 884 |
| KCNH6 | ETTSPGPRL-P------QGFLPPAQTPSYG>D<LDDCSP--------------KHRNSSPRMP | 919 |
| KCNH7 | ESDLTYGEV-EQRLDLLQEQLNRLESQMTT>D<IQTILQ--------------LLQKQTTVVP | 1068 |
| KCNH8 | EIGAAVLFI-KAEETK--QQINKLNSEVTT>L<TQEVSQ--------------LGKDMRNVIQ | 893 |
| CNGA1 | ------------------------------>-<------------------------------ | |
| CNGA2 | ------------------------------>-<------------------------------ | |
| CNGA3 | ------------------------------>-<------------------------------ | |
| CNGA4 | ------------------------------>-<------------------------------ | |
| CNGB1 | SPPPAS------------------------>-<------------------------------ | 1204 |
| CNGB3 | EEEPHS------------------------>-<------------------------------ | 769 |
| HCN1 | -STPKNEVH-KSTQALHNTNLTREVRPLSA>S<QPSLPHEVSTLISRPHPTVG----ESLASI | 815 |
| HCN2 | -PYGGLPAAPLAGPALPARRLSRASRPLSA>S<QPSLPHGAPGPAASTRPAS----------- | 842 |
| HCN3 | ---P----------GGGGRRLGPRGRPLSA>S<QPSLPQRATGDGSPGRKGS----------- | 734 |
| HCN4 | -PPPQVPQR-RGTPPLTPGRLTQDLKLISA>S<QPALPQDGAQTLRRASPHSSGESMAAFPLF | 1119 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.D1059E | c.3177C>G | Putative Benign | SIFT: Polyphen: |