Paralogue Annotation for KCNH2 residue 1060

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1060
Reference Amino Acid: M - Methionine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1060

No paralogue variants have been mapped to residue 1060 for KCNH2.



KCNH2GRRPRGDV-ESRLDALQRQLNRLETRLSAD>M<ATVLQ--------------LLQRQMTLVPP1076
KCNH1----RTKA-S-----GEATLKKTDSCDSGI>T<KSDLR--------------LDNVGEARSPQ901
KCNH3--LLTVPH-GPSEARNTDTLDKLRQAVTEL>S<EQVLQ--------------MREGLQSLRQA905
KCNH4P-SPELAS-EAEEVK--EKVCRLNQEISRL>N<QEVSQ--------------LSRELRHIMGL907
KCNH5KSSDSENS-V-----TKNPLRKTDSCDSGI>T<KSDLR--------------LDKAGEARSPL885
KCNH6TTSPGPRL-P------QGFLPPAQTPSYGD>L<DDCSP--------------KHRNSSPRMP-919
KCNH7SDLTYGEV-EQRLDLLQEQLNRLESQMTTD>I<QTILQ--------------LLQKQTTVVPP1069
KCNH8IGAAVLFI-KAEETK--QQINKLNSEVTTL>T<QEVSQ--------------LGKDMRNVIQL894
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1PPPAS------------------------->-<------------------------------1204
CNGB3EEPHS------------------------->-<------------------------------769
HCN1STPKNEVH-KSTQALHNTNLTREVRPLSAS>Q<PSLPHEVSTLISRPHPTVG----ESLASIP816
HCN2PYGGLPAAPLAGPALPARRLSRASRPLSAS>Q<PSLPHGAPGPAASTRPAS------------842
HCN3--P----------GGGGRRLGPRGRPLSAS>Q<PSLPQRATGDGSPGRKGS------------734
HCN4PPPQVPQR-RGTPPLTPGRLTQDLKLISAS>Q<PALPQDGAQTLRRASPHSSGESMAAFPLFP1120
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.M1060Vc.3178A>G Putative BenignSIFT:
Polyphen: