Paralogue Annotation for KCNH2 residue 1071

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1071
Reference Amino Acid: M - Methionine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1071

No paralogue variants have been mapped to residue 1071 for KCNH2.



KCNH2RLSADMATVLQ--------------LLQRQ>M<TLVPPAYSAVTTP-----------------1084
KCNH1CDSGITKSDLR--------------LDNVG>E<ARSPQDRSPILAEVKHSF------------914
KCNH3AVTELSEQVLQ--------------MREGL>Q<SLRQAVQLVLAPHREGP-------------917
KCNH4EISRLNQEVSQ--------------LSREL>R<HIMGLLQARLGPP-----------------915
KCNH5CDSGITKSDLR--------------LDKAG>E<ARSPLEHSPIQADAKHPF------------898
KCNH6PSYGDLDDCSP--------------KHRNS>S<PRMP--HLAVATD-----------------926
KCNH7QMTTDIQTILQ--------------LLQKQ>T<TVVPPAYSMVTAGSEYQR------------1082
KCNH8EVTTLTQEVSQ--------------LGKDM>R<NVIQLLENVLSPQQPSRFCSLHSTSVCPSR919
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1------------------------------>-<------------------------------
CNGB3------------------------------>-<------------------------------
HCN1PLSASQPSLPHEVSTLISRPHPTVG----E>S<LASIPQPVTAVPGTGLQ-------------828
HCN2PLSASQPSLPHGAPGPAASTRPAS------>-<------------------------------842
HCN3PLSASQPSLPQRATGDGSPGRKGS------>-<------------------------------734
HCN4LISASQPALPQDGAQTLRRASPHSSGESMA>A<FPLFPRAGGGSGGSGS--------------1131
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.M1071Vc.3211A>G Putative BenignSIFT: tolerated
Polyphen: benign