Paralogue Annotation for KCNH2 residue 1077

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1077
Reference Amino Acid: A - Alanine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1077

No paralogue variants have been mapped to residue 1077 for KCNH2.



KCNH2ATVLQ--------------LLQRQMTLVPP>A<YSAVTTP-----------------------1084
KCNH1KSDLR--------------LDNVGEARSPQ>D<RSPILAEVKHSF-------------YPIPE919
KCNH3EQVLQ--------------MREGLQSLRQA>V<QLVLAPHREGP-------------CPRAS-922
KCNH4QEVSQ--------------LSRELRHIMGL>L<QARLGPP------------------GHPAG920
KCNH5KSDLR--------------LDKAGEARSPL>E<HSPIQADAKHPF-------------YPIPE903
KCNH6DDCSP--------------KHRNSSPRMP->-<HLAVATD-----------------------926
KCNH7QTILQ--------------LLQKQTTVVPP>A<YSMVTAGSEYQR-------------PIIQL1087
KCNH8QEVSQ--------------LGKDMRNVIQL>L<ENVLSPQQPSRFCSLHSTSVCPSRESLQTR925
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1------------------------------>-<------------------------------
CNGB3------------------------------>-<------------------------------
HCN1PSLPHEVSTLISRPHPTVG----ESLASIP>Q<PVTAVPGTGLQ-----------------AG830
HCN2PSLPHGAPGPAASTRPAS------------>-<------------------------------842
HCN3PSLPQRATGDGSPGRKGS------------>-<------------------------------734
HCN4PALPQDGAQTLRRASPHSSGESMAAFPLFP>R<AGGGSGGSGS--------------------1131
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.A1077Tc.3229G>A Putative Benignrs201382073SIFT: deleterious
Polyphen: probably damaging
p.A1077Dc.3230C>A Putative BenignSIFT:
Polyphen: