Paralogue Annotation for KCNH2 residue 1087

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1087
Reference Amino Acid: G - Glycine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1087

No paralogue variants have been mapped to residue 1087 for KCNH2.



KCNH2VTTP------------------------GP>G<PTSTSPLL-----PVSPLP-TLTLDSLSQV1111
KCNH1ILAEVKHSF-------------YPIPEQTL>Q<ATVLEVRH-----ELKEDIKALNAKMTNIE948
KCNH3LAPHREGP-------------CPRAS---->-<GEGPCPASTSGLLQPLCVDTGASSYCLQPP952
KCNH4LGPP------------------GHPAGSAW>T<PDPPCPQL-----RP-----PCLSPCASRP944
KCNH5IQADAKHPF-------------YPIPEQAL>Q<TTLQEVKH-----ELKEDIQLLSCRMTALE932
KCNH6VATD------------------------KT>L<APSSEQEQ-----PEGLWP-PLASPLHPLE953
KCNH7VTAGSEYQR-------------PIIQLMRT>S<QPEASIKT-----DRSFSPSSQCPEFLDLE1116
KCNH8LSPQQPSRFCSLHSTSVCPSRESLQTRTSW>S<AHQPCLHL-----QTGGAAYTQAQLCSSNI954
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1---------------------------LGR>P<EGEEEGPA-----EPEEHSVRIC-------1226
CNGB3---------------------------VRR>-<---TVLPR-----GTSRQSLIIS-------787
HCN1AVPGTGLQ-----------------AG--->-<G---RST--------------VP-QRVTLF842
HCN2------------------------------>-<S---ST-------------PRLG-P-----850
HCN3------------------------------>-<G---SE-------------R-LP-PSGLL-745
HCN4GSGGSGS----------------------->-<S---GGLG-----PPGRPYGAIPGQHVTLP1153
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.G1087Dc.3260G>A Putative Benignrs369564588SIFT: tolerated
Polyphen: possibly damaging