Paralogue Annotation for KCNH2 residue 1092

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1092
Reference Amino Acid: S - Serine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1092

No paralogue variants have been mapped to residue 1092 for KCNH2.



KCNH2-----------------------GPGPTST>S<PLL-----PVSPLP-TLTLDSLSQVSQFMA1116
KCNH1KHSF-------------YPIPEQTLQATVL>E<VRH-----ELKEDIKALNAKMTNIEKQLSE953
KCNH3EGP-------------CPRAS-----GEGP>C<PASTSGLLQPLCVDTGASSYCLQPPAGSVL957
KCNH4-----------------GHPAGSAWTPDPP>C<PQL-----RP-----PCLSPCASRPPPSLQ949
KCNH5KHPF-------------YPIPEQALQTTLQ>E<VKH-----ELKEDIQLLSCRMTALEKQVAE937
KCNH6-----------------------KTLAPSS>E<QEQ-----PEGLWP-PLASPLHPLEVQGLI958
KCNH7EYQR-------------PIIQLMRTSQPEA>S<IKT-----DRSFSPSSQCPEFLDLEKSKLK1121
KCNH8PSRFCSLHSTSVCPSRESLQTRTSWSAHQP>C<LHL-----QTGGAAYTQAQLCSSNITSDIW959
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1----------------------LGRPEGEE>E<GPA-----EPEEHSVRIC------------1226
CNGB3----------------------VRR----T>V<LPR-----GTSRQSLIIS------------787
HCN1GLQ-----------------AG----G--->R<ST--------------VP-QRVTLFRQMSS847
HCN2--------------------------S--->S<T-------------PRLG-P----------850
HCN3--------------------------G--->S<E-------------R-LP-PSGLL------745
HCN4GS------------------------S--->G<GLG-----PPGRPYGAIPGQHVTLPRKTSS1158
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.S1092Fc.3275C>T Putative Benignrs147510453SIFT: deleterious
Polyphen: probably damaging