Paralogue Annotation for KCNH2 residue 1094

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1094
Reference Amino Acid: L - Leucine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1094

No paralogue variants have been mapped to residue 1094 for KCNH2.



KCNH2---------------------GPGPTSTSP>L<L-----PVSPLP-TLTLDSLSQVSQFMACE1118
KCNH1SF-------------YPIPEQTLQATVLEV>R<H-----ELKEDIKALNAKMTNIEKQLSEIL955
KCNH3P-------------CPRAS-----GEGPCP>A<STSGLLQPLCVDTGASSYCLQPPAGSVLSG959
KCNH4---------------GHPAGSAWTPDPPCP>Q<L-----RP-----PCLSPCASRPPPSLQDT951
KCNH5PF-------------YPIPEQALQTTLQEV>K<H-----ELKEDIQLLSCRMTALEKQVAEIL939
KCNH6---------------------KTLAPSSEQ>E<Q-----PEGLWP-PLASPLHPLEVQGLICG960
KCNH7QR-------------PIIQLMRTSQPEASI>K<T-----DRSFSPSSQCPEFLDLEKSKLKSK1123
KCNH8RFCSLHSTSVCPSRESLQTRTSWSAHQPCL>H<L-----QTGGAAYTQAQLCSSNITSDIWSV961
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1--------------------LGRPEGEEEG>P<A-----EPEEHSVRIC--------------1226
CNGB3--------------------VRR----TVL>P<R-----GTSRQSLIIS--------------787
HCN1Q-----------------AG----G---RS>T<--------------VP-QRVTLFRQMSSGA849
HCN2------------------------S---ST>-<------------PRLG-P------------850
HCN3------------------------G---SE>-<------------R-LP-PSGLL-------A746
HCN4------------------------S---GG>L<G-----PPGRPYGAIPGQHVTLPRKTSSGS1160
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.L1094Mc.3280C>A Putative BenignSIFT: tolerated
Polyphen: benign
p.L1094Rc.3281T>G Putative BenignSIFT: tolerated
Polyphen: benign