Paralogue Annotation for KCNH2 residue 1131

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1131
Reference Amino Acid: G - Glycine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1131

No paralogue variants have been mapped to residue 1131 for KCNH2.



KCNH2-----------------------------E>G<--------PTRRLSLPGQL---GALTSQP-1149
KCNH1------------------------------>-<---------------SQSP---QELFEISR975
KCNH3PRATAFWTSTSDSEPPASGDLCSEPSTPAS>-<------PPPSEEGAR-TGP---AEPVSQAE1037
KCNH4--------SILPPYPSEPDPLG-------->-<------PSPVPEASPPTPS---LLRHSFQS1011
KCNH5------------------------ASSPKS>Q<M------PLQVP--PQIPC---QDIFSVSR975
KCNH6------------------------------>-<--------P-CFSSLPEHL---GSVPKQLD978
KCNH7----------LKQDSDLSLELHLRQRKTYV>H<--------PIRHPSLPDSS---LSTVGIVG1183
KCNH8RCISPHSDSTLTPLQSISATLSSSVCSSSE>T<SLHLVLPSRSEEGSFSQGT---VSSFSLEN1067
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1------------------------------>-<-------------MSPGPEPGEQILSVKMP1243
CNGB3------------------------------>-<-------------MAPSAEGGEEVLTIEVK804
HCN1--------------------------PP-->-<-----------AAALPRES---SSVLNTD-878
HCN2--------------------------RR-->-<-----------DSASPGAA---GG---LD-876
HCN3--------------------------VP-->-<-----------EPATP--------------765
HCN4---------------------------P-->-<-----------LTAGPQRE---PG---AR-1191
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.G1131Vc.3392G>T Putative Benignrs370558996SIFT: tolerated
Polyphen: probably damaging