Paralogue Annotation for KCNH2 residue 1151

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1151
Reference Amino Acid: H - Histidine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1151

No paralogue variants have been mapped to residue 1151 for KCNH2.



KCNH2-------PTRRLSLPGQL---GALTSQP-L>H<RHGSDPG-----------------------1158
KCNH1--------------SQSP---QELFEISRP>Q<SPESERDIFGA-------------------988
KCNH3-----PPPSEEGAR-TGP---AEPVSQAEA>T<STGEPPPGSGGLALPWDPHSLEMVLIGCHG1069
KCNH4-----PSPVPEASPPTPS---LLRHSFQSR>S<DTF---------------------------1016
KCNH5------PLQVP--PQIPC---QDIFSVSRP>E<SPESDKDEIH--------------------987
KCNH6-------P-CFSSLPEHL---GSVPKQLDF>Q<RHGSDPGFAGSWG-----------------993
KCNH7-------PIRHPSLPDSS---LSTVGIVGL>H<RHVSDPGLPG--------------------1195
KCNH8LHLVLPSRSEEGSFSQGT---VSSFSLENL>P<GSWNQEGMASASTKPLENLPLEVVTS----1095
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1------------MSPGPEPGEQILSVKMPE>E<REE-KAE-----------------------1251
CNGB3------------MAPSAEGGEEVLTIEVKE>K<AKQ---------------------------809
HCN1----------AAALPRES---SSVLNTD-P>-<DAEKP-RFASN-------------------889
HCN2----------DSASPGAA---GG---LD-P>Q<DSARS-RLSSN-------------------888
HCN3----------EPATP--------------->-<--RGL-QLSAN-------------------773
HCN4----------LTAGPQRE---PG---AR-P>-<EPVRS-KLPSN-------------------1202
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.H1151Qc.3453C>A Putative BenignSIFT: tolerated
Polyphen: possibly damaging