Paralogue Annotation for KCNH2 residue 1154

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 1154
Reference Amino Acid: G - Glycine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 1154

No paralogue variants have been mapped to residue 1154 for KCNH2.



KCNH2----PTRRLSLPGQL---GALTSQP-LHRH>G<SDPG--------------------------1158
KCNH1-----------SQSP---QELFEISRPQSP>E<SERDIFGA----------------------988
KCNH3--PPPSEEGAR-TGP---AEPVSQAEATST>G<EPPPGSGGLALPWDPHSLEMVLIGCHGSGT1072
KCNH4--PSPVPEASPPTPS---LLRHSFQSRSDT>F<------------------------------1016
KCNH5---PLQVP--PQIPC---QDIFSVSRPESP>E<SDKDEIH-----------------------987
KCNH6----P-CFSSLPEHL---GSVPKQLDFQRH>G<SDPGFAGSWG--------------------993
KCNH7----PIRHPSLPDSS---LSTVGIVGLHRH>V<SDPGLPG-----------------------1195
KCNH8VLPSRSEEGSFSQGT---VSSFSLENLPGS>W<NQEGMASASTKPLENLPLEVVTS------T1096
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1---------MSPGPEPGEQILSVKMPEERE>E<-KAE--------------------------1251
CNGB3---------MAPSAEGGEEVLTIEVKEKAK>Q<------------------------------809
HCN1-------AAALPRES---SSVLNTD-P-DA>E<KP-RFASN----------------------889
HCN2-------DSASPGAA---GG---LD-PQDS>A<RS-RLSSN----------------------888
HCN3-------EPATP------------------>R<GL-QLSAN----------------------773
HCN4-------LTAGPQRE---PG---AR-P-EP>V<RS-KLPSN----------------------1202
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.G1154Sc.3460G>A Putative Benignrs199473548SIFT: tolerated
Polyphen: possibly damaging
ReportsPutative Benign Genetic polymorphisms in KCNQ1, HERG, KCNE1 and KCNE2 genes in the Chinese, Malay and Indian populations of Singapore. Br J Clin Pharmacol. 2006 61(3):301-8. 16487223