Paralogue Annotation for KCNH2 residue 131

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 131
Reference Amino Acid: V - Valine
Protein Domain: N-terminus

Paralogue Variants mapped to KCNH2 residue 131

No paralogue variants have been mapped to residue 131 for KCNH2.

KCNH2	----------PVK---NEDGAVIMFILNFE>V<VMEKDM-VG---------------------	139
KCNH1	----------PIR---NEQDKVVLFLCTFS>D<ITAFKQ-PI---------------------	140
KCNH3	----------PIK---NEKGEVALFLVSHK>D<ISETK-NRG---------------------	140
KCNH4	----------PIK---NEMGEVVLFLFSFK>D<ITQSGSPGL---------------------	141
KCNH5	----------PIR---NEHEKVVLFLCTFK>D<ITLFKQ-PI---------------------	138
KCNH6	----------PVK---NEDGAVIMFILNFE>D<LAQL--------------------------	135
KCNH7	----------PVK---NQEGVAMMFIINFE>Y<VTDNEN-AA---------------------	139
KCNH8	----------PIK---NEKGDVVLFLASFK>D<ITDTK-VKI---------------------	140
CNGA1	----------PSQREQYLPGAIALFNVNNS>S<NKDQ--------------------------	100
CNGA2	-----------FRRIVRLVGIIREWANKNF>R<EEEP--------------------------	89
CNGA3	-----------IARLSRLIFLLRRWAARHV>H<HQDQ--------------------------	93
CNGA4	------------------------------>-<--DT--------------------------	5
CNGB1	MALPQPVLHGKIG---EQEPDSPGICDVQT>I<SILPGG---QVEPDLVLEEVEPPWEDAHQD	319
CNGB3	------------------------------>-<------------------------------
HCN1	------------------------------>G<GGGGGG-GGG--------------------	72
HCN2	------------------------------>G<AASGPA-PGP--------------------	138
HCN3	------------------------------>T<AASGPI-PKS--------------------	40
HCN4	------------------------------>Q<PSVDTA-IKV--------------------	190
cons	> <

See full Alignment of Paralogues

Known Variants in KCNH2

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.V131L	c.391G>T	Putative Benign		rs142590566	SIFT: tolerated Polyphen: benign