Paralogue Annotation for KCNH2 residue 133

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 133
Reference Amino Acid: M - Methionine
Protein Domain: N-terminus

Paralogue Variants mapped to KCNH2 residue 133

No paralogue variants have been mapped to residue 133 for KCNH2.

KCNH2	--------PVK---NEDGAVIMFILNFEVV>M<EKDM-VG-----------------------	139
KCNH1	--------PIR---NEQDKVVLFLCTFSDI>T<AFKQ-PI-----------------------	140
KCNH3	--------PIK---NEKGEVALFLVSHKDI>S<ETK-NRG-----------------------	140
KCNH4	--------PIK---NEMGEVVLFLFSFKDI>T<QSGSPGL-----------------------	141
KCNH5	--------PIR---NEHEKVVLFLCTFKDI>T<LFKQ-PI-----------------------	138
KCNH6	--------PVK---NEDGAVIMFILNFEDL>A<QL----------------------------	135
KCNH7	--------PVK---NQEGVAMMFIINFEYV>T<DNEN-AA-----------------------	139
KCNH8	--------PIK---NEKGDVVLFLASFKDI>T<DTK-VKI-----------------------	140
CNGA1	--------PSQREQYLPGAIALFNVNNSSN>K<DQ----------------------------	100
CNGA2	---------FRRIVRLVGIIREWANKNFRE>E<EP----------------------------	89
CNGA3	---------IARLSRLIFLLRRWAARHVHH>Q<DQ----------------------------	93
CNGA4	------------------------------>-<DT----------------------------	5
CNGB1	LPQPVLHGKIG---EQEPDSPGICDVQTIS>I<LPGG---QVEPDLVLEEVEPPWEDAHQDVS	321
CNGB3	------------------------------>-<------------------------------
HCN1	----------------------------GG>G<GGGG-GGG----------------------	72
HCN2	----------------------------GA>A<SGPA-PGP----------------------	138
HCN3	----------------------------TA>A<SGPI-PKS----------------------	40
HCN4	----------------------------QP>S<VDTA-IKV----------------------	190
cons	> <

See full Alignment of Paralogues

Known Variants in KCNH2

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.Met133Thr	c.398T>C	Unknown			SIFT: Polyphen: