Paralogue Annotation for KCNH2 residue 150

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 150
Reference Amino Acid: P - Proline
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 150

No paralogue variants have been mapped to residue 150 for KCNH2.



KCNH2-------------------------TNHRG>P<PTSWLAPGRAKTFRLKLPALLALTARESSV180
KCNH1------------------------------>-<---------CKGWG----------------149
KCNH3------------------------------>-<---------WKETGGGRR------------153
KCNH4------------------------------>-<---------GRGDSNHEN------------154
KCNH5------------------------------>-<---------TKGWT----------------147
KCNH6------------------------------>-<----LAKCSSRSLSQRLLSQSFLGSEGSHG161
KCNH7--------------------------N--->-<PILPIKTVNRKFFGFKFPGLRVLTYRKQSL175
KCNH8------------------------------>-<------------DKKEDK------------149
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1EEEEEEEEEEEEEEVTEVLLDSCVVSQVGV>G<QSEEDGTRPQSTSDQKLWEEVGEEAKKEAE418
CNGB3ENNENEQS---------------------->S<RRNEEGSHPSNQSQQ----TTAQEENKGEE50
HCN1------------------------------>-<---------PAGG---F-------------81
HCN2------------------------------>-<---------EAGSEEAG-------------150
HCN3------------------------------>-<----------------G-------------41
HCN4------------------------------>-<----------AAGDQIL-------------201
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.P150Hc.449C>A BenignSIFT: tolerated
Polyphen: benign
p.Pro150Serc.448C>T UnknownSIFT:
Polyphen: