Paralogue Annotation for KCNH2 residue 154

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 154
Reference Amino Acid: W - Tryptophan
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 154

No paralogue variants have been mapped to residue 154 for KCNH2.



KCNH2---------------------TNHRGPPTS>W<LAPGRAKTFRLKLPALLALTARESSVRSGG184
KCNH1------------------------------>-<-----CKGWG--------------------149
KCNH3------------------------------>-<-----WKETGGGRR----------------153
KCNH4------------------------------>-<-----GRGDSNHEN----------------154
KCNH5------------------------------>-<-----TKGWT--------------------147
KCNH6------------------------------>-<LAKCSSRSLSQRLLSQSFLGSEGSHGRPGG165
KCNH7----------------------N----PIL>P<IKTVNRKFFGFKFPGLRVLTYRKQSLPQED179
KCNH8------------------------------>-<--------DKKEDK----------------149
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1EEEEEEEEEEVTEVLLDSCVVSQVGVGQSE>E<DGTRPQSTSDQKLWEEVGEEAKKEAEEKAK422
CNGB3NEQS----------------------SRRN>E<EGSHPSNQSQQ----TTAQEENKGEEKSLK54
HCN1------------------------------>-<-----PAGG---F-----------------81
HCN2------------------------------>-<-----EAGSEEAG-----------------150
HCN3------------------------------>-<------------G-----------------41
HCN4------------------------------>-<------AAGDQIL-----------------201
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.W154Rc.460T>C Putative BenignSIFT:
Polyphen: