Paralogue Annotation for KCNH2 residue 227

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 227
Reference Amino Acid: P - Proline
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 227

No paralogue variants have been mapped to residue 227 for KCNH2.



KCNH2DVDLTPAAPSSESLALDEVTAMDNHVAGLG>P<AEERRALVGPGS-----------------P240
KCNH1------------------------------>-<------------------------------
KCNH3------------------------------>-<------------------------------
KCNH4------------------------------>-<------------------------------
KCNH5------------------------------>-<------------------------------
KCNH6------------------------------>P<G-----------------------------169
KCNH7DS----SKHSDDSVAMKHFKSPTKESCSPS>E<ADDTKALIQPSK-----------------C225
KCNH8------------------------------>-<------------------------------
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1KEPQDWAETKEEPEAEAEAASSGVPATKQH>P<EVQVEDTDADSCPLMAEENPPSTVLPPPSP495
CNGB3TNIQDKLSKKN---------SSGDLTTNPD>P<QNAAEPTGT---------------------97
HCN1------------------------------>-<------------------------------
HCN2------------------------------>-<------------------------------
HCN3------------------------------>-<------------------------------
HCN4------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.P227Tc.679C>A Putative Benignrs199521633SIFT: tolerated
Polyphen: benign