Paralogue Annotation for KCNH2 residue 233

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 233
Reference Amino Acid: A - Alanine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 233

No paralogue variants have been mapped to residue 233 for KCNH2.



KCNH2AAPSSESLALDEVTAMDNHVAGLGPAEERR>A<LVGPGS-----------------P--PRSA244
KCNH1------------------------------>-<------------------------------
KCNH3------------------------------>-<------------------------------
KCNH4------------------------------>-<------------------------------
KCNH5------------------------------>-<------------------------------
KCNH6------------------------PG---->-<------------------------------169
KCNH7SKHSDDSVAMKHFKSPTKESCSPSEADDTK>A<LIQPSK-----------------CSPLVNI231
KCNH8------------------------------>-<------------------------------
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1AETKEEPEAEAEAASSGVPATKQHPEVQVE>D<TDADSCPLMAEENPPSTVLPPPSPA---KS498
CNGB3LSKKN---------SSGDLTTNPDPQNAAE>P<TGT---------------------------97
HCN1------------------------------>-<------------------------------
HCN2------------------------------>-<------------------------------
HCN3------------------------------>-<------------------------------
HCN4------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.A233Sc.697G>T Putative BenignSIFT:
Polyphen:
p.A233Tc.697G>A UnknownSIFT: tolerated
Polyphen: benign