Paralogue Annotation for KCNH2 residue 245

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 245
Reference Amino Acid: P - Proline
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 245

No paralogue variants have been mapped to residue 245 for KCNH2.



KCNH2GPGS-----------------P--PRSA-->P<GQLPS--PRAHSLNPDASGSS------CSL267
KCNH1------------------------------>-<------------------------------
KCNH3------------------------------>-<----------------------------RY155
KCNH4------------------------------>-<----------------------------SL156
KCNH5------------------------------>-<------------------------------
KCNH6------------------------------>-<------------------------------
KCNH7QPSK-----------------CSPLVNISG>P<LDHSSPKRQWDRLYPDMLQSS------SQL258
KCNH8------------------------------>-<----------------------------VK151
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1ADSCPLMAEENPPSTVLPPPSPA---KS-->-<---------------DTLIVPSSASGTHRK513
CNGB3T----------------------------->-<-------------------VP---------99
HCN1------------------------------>-<------------------------------
HCN2------------------------------>-<------------------------------
HCN3------------------------------>-<------------------------------
HCN4------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.P245Hc.734C>A UnknownSIFT: deleterious
Polyphen: probably damaging