Paralogue Annotation for KCNH2 residue 270

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 270
Reference Amino Acid: T - Threonine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 270

No paralogue variants have been mapped to residue 270 for KCNH2.



KCNH2-PRAHSLNPDASGSS------CSL----AR>T<RSRESCASVRRASSADDIEAM--------R292
KCNH1------------------------------>-<------------------------------
KCNH3----------------------RY----GR>A<R-----------------------------159
KCNH4----------------------SL----GR>R<G-----------------------------160
KCNH5------------------------------>-<------------------------------
KCNH6------------------------------>-<------------------------------
KCNH7KRQWDRLYPDMLQSS------SQL----SH>S<RSRESLCSIRRASSVHDIEGFGVHPKNIFR291
KCNH8----------------------VK----GR>S<R-----------------------------155
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1---------DTLIVPSSASGTHRKKLPSED>D<EA-E---------ELKALSPAESPVVAWSD540
CNGB3-------------VP--------------->-<-------------EQKEMDPGKE------G110
HCN1------------------------------>-<------------------------------
HCN2------------------------------>-<------------------------------
HCN3------------------------------>-<------------------------------
HCN4------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.T270Mc.809C>T UnknownSIFT: deleterious
Polyphen: possibly damaging