Paralogue Annotation for KCNH2 residue 272

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 272
Reference Amino Acid: S - Serine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 272

No paralogue variants have been mapped to residue 272 for KCNH2.



KCNH2RAHSLNPDASGSS------CSL----ARTR>S<RESCASVRRASSADDIEAM--------RAG294
KCNH1------------------------------>-<------------------------------
KCNH3--------------------RY----GRAR>-<------------------------------159
KCNH4--------------------SL----GRRG>-<------------------------------160
KCNH5------------------------------>-<------------------------------
KCNH6------------------------------>-<------------------------------
KCNH7QWDRLYPDMLQSS------SQL----SHSR>S<RESLCSIRRASSVHDIEGFGVHPKNIFRDR293
KCNH8--------------------VK----GRSR>-<------------------------------155
CNGA1------------------------------>-<------------------------------
CNGA2------------------------------>-<------------------------------
CNGA3------------------------------>-<------------------------------
CNGA4------------------------------>-<------------------------------
CNGB1-------DTLIVPSSASGTHRKKLPSEDDE>A<-E---------ELKALSPAESPVVAWSDPT542
CNGB3-----------VP----------------->-<-----------EQKEMDPGKE------GPN112
HCN1------------------------------>-<------------------------------
HCN2------------------------------>-<------------------------------
HCN3------------------------------>-<------------------------------
HCN4------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.S272Tc.814T>A Putative Benignrs13229961SIFT: deleterious
Polyphen: probably damaging