Paralogue Annotation for KCNH2 residue 285

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 285
Reference Amino Acid: A - Alanine
Protein Domain: N-terminus

Paralogue Variants mapped to KCNH2 residue 285

No paralogue variants have been mapped to residue 285 for KCNH2.

KCNH2	------CSL----ARTRSRESCASVRRASS>A<DDIEAM--------RAGVLPPPPRHASTGA	307
KCNH1	------------------------------>-<------------------------------
KCNH3	-------RY----GRAR------------->-<------------------------------	159
KCNH4	-------SL----GRRG------------->-<------------------------------	160
KCNH5	------------------------------>-<------------------------------
KCNH6	------------------------------>-<------------------------------
KCNH7	------SQL----SHSRSRESLCSIRRASS>V<HDIEGFGVHPKNIFRDRHASEDNGRNVKGP	306
KCNH8	-------VK----GRSR------------->-<------------------------------	155
CNGA1	------------------------------>-<------------------------------
CNGA2	------------------------------>-<------------------------------
CNGA3	------------------------------>-<------------------------------
CNGA4	------------------------------>-<------------------------------
CNGB1	SSASGTHRKKLPSEDDEA-E---------E>L<KALSPAESPVVAWSDPTTPKDTDGQDRAAS	555
CNGB3	-----------------------------E>Q<KEMDPGKE------GPNSPQNK------PP	119
HCN1	------------------------------>-<------------------------------
HCN2	------------------------------>-<------------------------------
HCN3	------------------------------>-<------------------------------
HCN4	------------------------------>-<------------------------------
cons	> <

See full Alignment of Paralogues

Known Variants in KCNH2

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.Ala285Thr	c.853G>A	Unknown			SIFT: Polyphen:
p.Ala285Ser	c.853G>T	Unknown			SIFT: Polyphen: