Paralogue Annotation for KCNH2 residue 321

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 321
Reference Amino Acid: D - Aspartate
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 321

No paralogue variants have been mapped to residue 321 for KCNH2.



KCNH2-RAGVLPPPPRHASTGAMHPLRSGLLNSTS>D<SDLVRYR---TISKIPQITLNFVDLKGDPF348
KCNH1------------------------------>-<----KFA------------------RLTRA157
KCNH3------------------------------>-<-----S------------------KGFNAN166
KCNH4------------------------------>-<-----A-----------------TWKFRSA168
KCNH5------------------------------>-<----KFA------------------RLTRA155
KCNH6------------------------------>-<TGRGKYR---TISQIPQFTLNFVEFNLEKH196
KCNH7FRDRHASEDNGRNVKGPFNHIKSSLLGSTS>D<SNLNKYS---TINKIPQLTLNFSEVKTEKK347
KCNH8------------------------------>-<-----A-----------------GTHFDSA163
CNGA1------------------------------>-<---------------------KKK-KKKEK112
CNGA2------------------------------>-<---------------------FLE-RFRGP101
CNGA3------------------------------>-<---------------------FPD-RFRGA105
CNGA4------------------------------>-<------------------------------
CNGB1SDPTTPKDTDGQDRAASTASTNSAIINDRL>Q<ELVKLFKERTEKV-KEKLIDPDVTSDEE-S597
CNGB3-GPNSPQNK------PPAAPVINEYADAQL>H<NLVKRMRQRTALY-KKKLVEGDLSS-----157
HCN1------------------------------>-<-------------------------EDAEG86
HCN2------------------------------>-<-------------------------PAGEP155
HCN3------------------------------>-<-------------------------PE---43
HCN4------------------------------>-<-------------------------PEAEV206
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.Asp321Tyrc.961G>T UnknownSIFT:
Polyphen: