Paralogue Annotation for KCNH2 residue 325

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 325
Reference Amino Acid: V - Valine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 325

No paralogue variants have been mapped to residue 325 for KCNH2.



KCNH2VLPPPPRHASTGAMHPLRSGLLNSTSDSDL>V<RYR---TISKIPQITLNFVDLKGDPFLASP352
KCNH1------------------------------>-<KFA------------------RLTRALTSS161
KCNH3------------------------------>-<-S------------------KGFNANRRRS170
KCNH4------------------------------>-<-A-----------------TWKFRSARRRS172
KCNH5------------------------------>-<KFA------------------RLTRALTNS159
KCNH6---------------------------TGR>G<KYR---TISQIPQFTLNFVEFNLEKHRSSS200
KCNH7HASEDNGRNVKGPFNHIKSSLLGSTSDSNL>N<KYS---TINKIPQLTLNFSEVKTEKKNSSP351
KCNH8------------------------------>-<-A-----------------GTHFDSARRRS167
CNGA1------------------------------>-<-----------------KKK-KKKEKKSKS116
CNGA2------------------------------>-<-----------------FLE-RFRGPELQT105
CNGA3------------------------------>-<-----------------FPD-RFRGAELKE109
CNGA4------------------------------>-<--------------------------KVKT9
CNGB1TPKDTDGQDRAASTASTNSAIINDRLQELV>K<LFKERTEKV-KEKLIDPDVTSDEE-SPKPS601
CNGB3SPQNK------PPAAPVINEYADAQLHNLV>K<RMRQRTALY-KKKLVEGDLSS-----PEAS161
HCN1------------------------------>-<---------------------EDAEGPR-R89
HCN2------------------------------>-<---------------------PAGEPRG-S158
HCN3------------------------------>-<---------------------PE------P44
HCN4------------------------------>-<---------------------PEAEVRL-G209
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.V325Mc.973G>A Putative Benignrs149381387SIFT: tolerated
Polyphen: benign