Paralogue Annotation for KCNH2 residue 327

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 327
Reference Amino Acid: Y - Tyrosine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 327

No paralogue variants have been mapped to residue 327 for KCNH2.



KCNH2PPPPRHASTGAMHPLRSGLLNSTSDSDLVR>Y<R---TISKIPQITLNFVDLKGDPFLASP-T353
KCNH1-----------------------------K>F<A------------------RLTRALTSS-R162
KCNH3------------------------------>S<------------------KGFNANRRRS-R171
KCNH4------------------------------>A<-----------------TWKFRSARRRS-R173
KCNH5-----------------------------K>F<A------------------RLTRALTNS-R160
KCNH6-------------------------TGRGK>Y<R---TISQIPQFTLNFVEFNLEKHRSSS-T201
KCNH7SEDNGRNVKGPFNHIKSSLLGSTSDSNLNK>Y<S---TINKIPQLTLNFSEVKTEKKNSSPPS353
KCNH8------------------------------>A<-----------------GTHFDSARRRS-R168
CNGA1------------------------------>-<---------------KKK-KKKEKKSKS-D117
CNGA2------------------------------>-<---------------FLE-RFRGPELQT-V106
CNGA3------------------------------>-<---------------FPD-RFRGAELKE-V110
CNGA4------------------------------>-<------------------------KVKT-T10
CNGB1KDTDGQDRAASTASTNSAIINDRLQELVKL>F<KERTEKV-KEKLIDPDVTSDEE-SPKPSPA603
CNGB3QNK------PPAAPVINEYADAQLHNLVKR>M<RQRTALY-KKKLVEGDLSS-----PEASPQ163
HCN1------------------------------>-<-------------------EDAEGPR-R-Q90
HCN2------------------------------>-<-------------------PAGEPRG-S-Q159
HCN3------------------------------>-<-------------------PE------P--44
HCN4------------------------------>-<-------------------PEAEVRL-G-Q210
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.Y327Hc.979T>C Putative BenignSIFT:
Polyphen:
p.Tyr327Cysc.980A>G UnknownSIFT:
Polyphen: