Paralogue Annotation for KCNH2 residue 340

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 340
Reference Amino Acid: F - Phenylalanine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 340

No paralogue variants have been mapped to residue 340 for KCNH2.



KCNH2SGLLNSTSDSDLVRYR---TISKIPQITLN>F<VDLKGDPFLASP-T-SDREII-AP-KIK-E365
KCNH1-------------KFA-------------->-<---RLTRALTSS-R-GVLQQL-APS-VQKG175
KCNH3--------------S--------------->-<--KGFNANRRRS-R-AVLYHL-SGH-LQK-183
KCNH4--------------A--------------->-<-TWKFRSARRRS-R-TVLHRL-TGH-FGR-185
KCNH5-------------KFA-------------->-<---RLTRALTNS-R-SVLQQL-TPM-NKT-172
KCNH6---------TGRGKYR---TISQIPQFTLN>F<VEFNLEKHRSSS-T-TEIEII-APHKVV-E214
KCNH7SSLLGSTSDSNLNKYS---TINKIPQLTLN>F<SEVKTEKKNSSPPS-SDKTII-AP-KVK-D365
KCNH8--------------A--------------->-<-GTHFDSARRRS-R-AVLYHI-SGH-LQR-180
CNGA1------------------------------>K<KK-KKKEKKSKS-D-DKNENKNDPE-KK--129
CNGA2------------------------------>F<LE-RFRGPELQT-V-TTQEGDGKG--D---116
CNGA3------------------------------>F<PD-RFRGAELKE-V-SSQESNAQ-A-NVGS123
CNGA4------------------------------>-<--------KVKT-T-ES-------------12
CNGB1SAIINDRLQELVKLFKERTEKV-KEKLIDP>D<VTSDEE-SPKPSPA-KKAPEP-APD-TKPA616
CNGB3NEYADAQLHNLVKRMRQRTALY-KKKLVEG>D<LSS-----PEASPQ-TAKPTA-VPP-VKES176
HCN1------------------------------>-<---EDAEGPR-R-QYGFMQRQ--FT-SM--101
HCN2------------------------------>-<---PAGEPRG-S-QASFMQRQ--FG-AL--170
HCN3------------------------------>-<---PE------P-----KRRH--LG-TL--52
HCN4------------------------------>-<---PEAEVRL-G-QAGFMQRQ--FG-AM--221
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.F340Lc.1020T>G Putative BenignSIFT:
Polyphen: