Paralogue Annotation for KCNH2 residue 345

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 345
Reference Amino Acid: G - Glycine
Protein Domain: N-terminus


Paralogue Variants mapped to KCNH2 residue 345

No paralogue variants have been mapped to residue 345 for KCNH2.



KCNH2STSDSDLVRYR---TISKIPQITLNFVDLK>G<DPFLASP-T-SDREII-AP-KIK-E--R-T367
KCNH1--------KFA------------------R>L<TRALTSS-R-GVLQQL-APS-VQKG--E-N177
KCNH3---------S------------------KG>F<NANRRRS-R-AVLYHL-SGH-LQK---Q-P185
KCNH4---------A-----------------TWK>F<RSARRRS-R-TVLHRL-TGH-FGR---R-G187
KCNH5--------KFA------------------R>L<TRALTNS-R-SVLQQL-TPM-NKT---E-V174
KCNH6----TGRGKYR---TISQIPQFTLNFVEFN>L<EKHRSSS-T-TEIEII-APHKVV-E--R-T216
KCNH7STSDSNLNKYS---TINKIPQLTLNFSEVK>T<EKKNSSPPS-SDKTII-AP-KVK-D--R-T367
KCNH8---------A-----------------GTH>F<DSARRRS-R-AVLYHI-SGH-LQR---R-E182
CNGA1-------------------------KKK-K>K<KEKKSKS-D-DKNENKNDPE-KK-------129
CNGA2-------------------------FLE-R>F<RGPELQT-V-TTQEGDGKG--D--------116
CNGA3-------------------------FPD-R>F<RGAELKE-V-SSQESNAQ-A-NVGS--QEP126
CNGA4------------------------------>-<---KVKT-T-ES------------------12
CNGB1DRLQELVKLFKERTEKV-KEKLIDPDVTSD>E<E-SPKPSPA-KKAPEP-APD-TKPAEAE-P620
CNGB3AQLHNLVKRMRQRTALY-KKKLVEGDLSS->-<---PEASPQ-TAKPTA-VPP-VKES--D-D178
HCN1-----------------------------E>D<AEGPR-R-QYGFMQRQ--FT-SM----L-Q103
HCN2-----------------------------P>A<GEPRG-S-QASFMQRQ--FG-AL----L-Q172
HCN3-----------------------------P>E<------P-----KRRH--LG-TL----L-Q54
HCN4-----------------------------P>E<AEVRL-G-QAGFMQRQ--FG-AM----L-Q223
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.G345Sc.1033G>A Putative BenignSIFT:
Polyphen: