Paralogue Annotation for KCNH2 residue 438

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 438
Reference Amino Acid: E - Glutamate
Protein Domain: Transmembrane/Linker/Pore


Paralogue Variants mapped to KCNH2 residue 438

No paralogue variants have been mapped to residue 438 for KCNH2.



KCNH2-VWDWLILLLVIYTAVFTPYSAAFLLKETE>E<GPPATECGYACQPLAVVDLIVDIMFIVDI-467
KCNH1-TWDWIILILTFYTAILVPYNVSFKTRQN->-<----------NVAWLVVDSIVDVIFLVDI-265
KCNH3-TWDGFILLATLYVAVTVPYSVCVSTARE->-<------PSAARGPPSVCDLAVEVLFILDI-276
KCNH4-IWDGLILLATFYVAVTVPYNVCFSGDDD->-<------TPITSRHTLVSDIAVEMLFILDI-278
KCNH5-TWDWVILILTFYTAIMVPYNVSFKTKQN->-<----------NIAWLVLDSVVDVIFLVDI-262
KCNH6-VWDWLILLLVIYTAVFTPYSAAFLLSDQD>E<-SRRGACSYTCSPLTVVDLIVDIMFVVDI-315
KCNH7-VWDWLILLLVIYTAIFTPYSAAFLLNDRE>E<-QKRRECGYSCSPLNVVDLIVDIMFIIDI-466
KCNH8-GWDWLILLATFYVAVTVPYNVCFIGNDD->-<------LS-TTRSTTVSDIAVEILFIIDI-272
CNGA1-NWLFCITLPVMYNWTMVIARACFDELQS->-<--------DYLEYWLILDYVSDIVYLIDM-215
CNGA2-CWLFVIAMPVLYNWCLLVARACFSDLQK->-<--------GYYLVWLVLDYVSDVVYIADL-190
CNGA3-RWLTAIALPVFYNWYLLICRACFDELQS->-<--------EYLMLWLVLDYSADVLYVLDV-218
CNGA4-WWLNTMVFPVMYNLIILVCRACFPDLQH->-<--------GYLVAWLVLDYTSDLLYLLDM-84
CNGB1VLWLFFVVMAWNWNCWLIPVRWAFPYQTP->-<--------DNIHHWLLMDYLCDLIYFLDIT707
CNGB3LLWLLLVTLAYNWNCCFIPLRLVFPYQTA->-<--------DNIHYWLIADIICDIIYLYDML269
HCN1-YWDLIMLIMMVGNLVIIPVGITFFTEQT->-<----------TTPWIIFNVASDTVFLLDL-190
HCN2-YWDFTMLLFMVGNLIIIPVGITFFKDET->-<----------TAPWIVFNVVSDTFFLMDL-259
HCN3-YWDLIMLLLMVGNLIVLPVGITFFKEEN->-<----------SPPWIVFNVLSDTFFLLDL-141
HCN4-YWDLTMLLLMVGNLIIIPVGITFFKDEN->-<----------TTPWIVFNVVSDTFFLIDL-310
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.E438Kc.1312G>A Putative BenignSIFT:
Polyphen: