Paralogue Annotation for KCNH2 residue 458

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 458
Reference Amino Acid: I - Isoleucine
Protein Domain: Transmembrane/Linker/Pore

Paralogue Variants mapped to KCNH2 residue 458

No paralogue variants have been mapped to residue 458 for KCNH2.

KCNH2	SAAFLLKETEEGPPATECGYACQPLAVVDL>I<VDIMFIVDI-LINFRTTYVN-ANEEVVSHP	486
KCNH1	NVSFKTRQN------------NVAWLVVDS>I<VDVIFLVDI-VLNFHTTFVG-PAGEVISDP	284
KCNH3	SVCVSTARE--------PSAARGPPSVCDL>A<VEVLFILDI-VLNFRTTFVS-KSGQVVFAP	295
KCNH4	NVCFSGDDD--------TPITSRHTLVSDI>A<VEMLFILDI-ILNFRTTYVS-QSGQVISAP	297
KCNH5	NVSFKTKQN------------NIAWLVLDS>V<VDVIFLVDI-VLNFHTTFVG-PGGEVISDP	281
KCNH6	SAAFLLSDQDE-SRRGACSYTCSPLTVVDL>I<VDIMFVVDI-VINFRTTYVN-TNDEVVSHP	334
KCNH7	SAAFLLNDREE-QKRRECGYSCSPLNVVDL>I<VDIMFIIDI-LINFRTTYVN-QNEEVVSDP	485
KCNH8	NVCFIGNDD--------LS-TTRSTTVSDI>A<VEILFIIDI-ILNFRTTYVS-KSGQVIFEA	291
CNGA1	RACFDELQS----------DYLEYWLILDY>V<SDIVYLIDM-FVRTRTGYLE--QGLLVKEE	233
CNGA2	RACFSDLQK----------GYYLVWLVLDY>V<SDVVYIADL-FIRLRTGFLE--QGLLVKDT	208
CNGA3	RACFDELQS----------EYLMLWLVLDY>S<ADVLYVLDV-LVRARTGFLE--QGLMVSDT	236
CNGA4	RACFPDLQH----------GYLVAWLVLDY>T<SDLLYLLDM-VVRFHTGFLE--QGILVVDK	102
CNGB1	RWAFPYQTP----------DNIHHWLLMDY>L<CDLIYFLDITVFQTRLQFVR--GGDIITDK	725
CNGB3	RLVFPYQTA----------DNIHYWLIADI>I<CDIIYLYDMLFIQPRLQFVR--GGDIIVDS	287
HCN1	GITFFTEQT------------TTPWIIFNV>A<SDTVFLLDL-IMNFRTGTVNEDSSEIILDP	210
HCN2	GITFFKDET------------TAPWIVFNV>V<SDTFFLMDL-VLNFRTGIVIEDNTEIILDP	279
HCN3	GITFFKEEN------------SPPWIVFNV>L<SDTFFLLDL-VLNFRTGIVVEEGAEILLAP	161
HCN4	GITFFKDEN------------TTPWIVFNV>V<SDTFFLIDL-VLNFRTGIVVEDNTEIILDP	330
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See full Alignment of Paralogues

Known Variants in KCNH2

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.I458V	c.1372A>G	Putative Benign		rs374303744	SIFT: tolerated Polyphen: benign