Paralogue Annotation for KCNH2 residue 491

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 491
Reference Amino Acid: V - Valine
Protein Domain: Transmembrane/Linker/Pore


Paralogue Variants mapped to KCNH2 residue 491

No paralogue variants have been mapped to residue 491 for KCNH2.



KCNH2FIVDI-LINFRTTYVN-ANEEVVSHPGRIA>V<HYFKGW-FLIDMVAAIPFDLLIFGSGSEE-519
KCNH1FLVDI-VLNFHTTFVG-PAGEVISDPKLIR>M<NYLKTW-FVIDLLSCLPYDVINAFENVDEV318
KCNH3FILDI-VLNFRTTFVS-KSGQVVFAPKSIC>L<HYVTTW-FLLDVIAALPFDLLHAF-KVN--326
KCNH4FILDI-ILNFRTTYVS-QSGQVISAPRSIG>L<HYLATW-FFIDLIAALPFDLLYIF-NIT--328
KCNH5FLVDI-VLNFHTTFVG-PGGEVISDPKLIR>M<NYLKTW-FVIDLLSCLPYDIINAFENVDEG315
KCNH6FVVDI-VINFRTTYVN-TNDEVVSHPRRIA>V<HYFKGW-FLIDMVAAIPFDLLIFRTGSDE-367
KCNH7FIIDI-LINFRTTYVN-QNEEVVSDPAKIA>I<HYFKGW-FLIDMVAAIPFDLLIFGSGSDE-518
KCNH8FIIDI-ILNFRTTYVS-KSGQVIFEARSIC>I<HYVTTW-FIIDLIAALPFDLLYAF-NVT--322
CNGA1YLIDM-FVRTRTGYLE--QGLLVKEELKLI>N<KYKSNLQFKLDVLSLIPTDLLYFKLGWNY-267
CNGA2YIADL-FIRLRTGFLE--QGLLVKDTKKLR>D<NYIHTLQFKLDVASIIPTDLIYFAVDIHS-242
CNGA3YVLDV-LVRARTGFLE--QGLMVSDTNRLW>Q<HYKTTTQFKLDVLSLVPTDLAYLKVGTNY-270
CNGA4YLLDM-VVRFHTGFLE--QGILVVDKGRIS>S<RYVRTWSFFLDLASLMPTDVVYVRLGPHT-136
CNGB1YFLDITVFQTRLQFVR--GGDIITDKKDMR>N<NYLKSRRFKMDLLSLLPLDFLYLKVGVN--758
CNGB3YLYDMLFIQPRLQFVR--GGDIIVDSNELR>K<HYRTSTKFQLDVASIIPFDICYLFFGFN--320
HCN1FLLDL-IMNFRTGTVNEDSSEIILDPKVIK>M<NYLKSW-FVVDFISSIPVDYIFLIVEK--G242
HCN2FLMDL-VLNFRTGIVIEDNTEIILDPEKIK>K<KYLRTW-FVVDFVSSIPVDYIFLIVEK--G311
HCN3FLLDL-VLNFRTGIVVEEGAEILLAPRAIR>T<RYLRTW-FLVDLISSIPVDYIFLVVELEPR195
HCN4FLIDL-VLNFRTGIVVEDNTEIILDPQRIK>M<KYLKSW-FMVDFISSIPVDYIFLIVET--R362
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.V491Ic.1471G>A Putative Benignrs374376640SIFT: tolerated
Polyphen: benign