Paralogue Annotation for KCNH2 residue 538

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 538
Reference Amino Acid: K - Lysine
Protein Domain: Transmembrane/Linker/Pore


Paralogue Variants mapped to KCNH2 residue 538

No paralogue variants have been mapped to residue 538 for KCNH2.



KCNH2------------LIGLLKTARLLRLVRVAR>K<LDRY-----SEYGAAV-LFLLMCTFALIAH562
KCNH1PLEGRESQGISSLFSSLKVVRLLRLGRVAR>K<LDHY-----IEYGAAV-LVLLVCVFGLAAH391
KCNH3-----------FGAHLLKTVRLLRLLRLLP>R<LDRY-----SQYSAVV-LTLLMAVFALLAH372
KCNH4-----------SLVHLLKTVRLLRLLRLLQ>K<LERY-----SQCSAVV-LTLLMSVFALLAH374
KCNH5---------ISSLFSSLKVVRLLRLGRVAR>K<LDHY-----LEYGAAV-LVLLVCVFGLVAH361
KCNH6-----------TLIGLLKTARLLRLVRVAR>K<LDRY-----SEYGAAV-LFLLMCTFALIAH413
KCNH7-----------TLIGLLKTARLLRLVRVAR>K<LDRY-----SEYGAAV-LMLLMCIFALIAH564
KCNH8-----------SLVHLLKTVRLLRLLRLLQ>K<LDRY-----SQHSTIV-LTLLMSMFALLAH368
CNGA1-----------PEIRLNRLLRFSRMFEFFQ>R<TETR-----TNYPNIFRISNLVMYIVIIIH312
CNGA2-----------PEVRFNRLLHFARMFEFFD>R<TETR-----TNYPNIFRISNLVLYILVIIH287
CNGA3-----------PEVRFNRLLKFSRLFEFFD>R<TETR-----TNYPNMFRIGNLVLYILIIIH315
CNGA4-----------PTLRLNRFLRAPRLFEAFD>R<TETR-----TAYPNAFRIAKLMLYIFVVIH181
CNGB1-----------PLLRLPRCLKYMAFFEFNS>R<LESI-----LSKAYVYRVIRTTAYLLYSLH803
CNGB3-----------PMFRANRMLKYTSFFEFNH>H<LESI-----MDKAYIYRVIRTTGYLLFILH365
HCN1-----------KILSLLRLLRLSRLIRYIH>Q<WEEIFHMTYDLASAVVRIFNLIGMMLLLCH310
HCN2-----------KILSLLRLLRLSRLIRYIH>Q<WEEIFHMTYDLASAVMRICNLISMMLLLCH379
HCN3-----------KILSLLRLLRLSRLIRYIH>Q<WEEIFHMTYDLASAVVRIFNLIGMMLLLCH263
HCN4-----------KILSLLRLLRLSRLIRYIH>Q<WEEIFHMTYDLASAVVRIVNLIGMMLLLCH430
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.Lys538Gluc.1612A>G UnknownSIFT:
Polyphen: