Paralogue Annotation for KCNH2 residue 602

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 602
Reference Amino Acid: L - Leucine
Protein Domain: Transmembrane/Linker/Pore


Paralogue Variants mapped to KCNH2 residue 602

No paralogue variants have been mapped to residue 602 for KCNH2.



KCNH2S----------G------------------>L<GGPSIKDKYVTALYFTFSSLTSVGFGNVSP632
KCNH1N--------GSG-----------S--GK-W>E<GGPSKNSVYISSLYFTMTSLTSVGFGNIAP471
KCNH3VGRRPAGGNSSGQSDNCSSSSEANGTGLEL>L<GGPSLRSAYITSLYFALSSLTSVGFGNVSA473
KCNH4G----------------------------S>V<GGPSRRSAYIAALYFTLSSLTSVGFGNVCA447
KCNH5N--------T-S-----------A--GI-W>E<GGPSKDSLYVSSLYFTMTSLTTIGFGNIAP440
KCNH6S----------D-----------P------>A<SGPSVQDKYVTALYFTFSSLTSVGFGNVSP484
KCNH7S----------D-----------S------>S<SGPSIKDKYVTALYFTFSSLTSVGFGNVSP635
KCNH8NN---------------------------T>L<GGPSIRSAYIAALYFTLSSLTSVGFGNVSA442
CNGA1------------------------------>-<EFGRLARKYVYSLYWSTLTLTTIG-ETPPP369
CNGA2------------------------------>-<EYGYLAREYIYCLYWSTLTLTTIG-ETPPP344
CNGA3------------------------------>-<EHGRLSRKYIYSLYWSTLTLTTIG-ETPPP372
CNGA4------------------------------>-<GFERLRRQYLYSFYFSTLILTTVG-DTPPP238
CNGB1------------------------------>-<---GVGNSYIRCYYFAVKTLITIG-GLPDP852
CNGB3------------------------------>-<---GEGNEYLRCYYWAVRTLITIG-GLPEP414
HCN1------------------------------>-<VNDSWGKQYSYALFKAMSHMLCIGYGAQAP366
HCN2------------------------------>-<VNHSWSELYSFALFKAMSHMLCIGYGRQAP435
HCN3------------------------------>-<VNHSWGRQYSHALFKAMSHMLCIGYGQQAP319
HCN4------------------------------>-<VNNSWGKQYSYALFKAMSHMLCIGYGRQAP486
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.Leu602Proc.1805T>C UnknownSIFT:
Polyphen: