Paralogue Annotation for KCNH2 residue 646

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 646
Reference Amino Acid: L - Leucine
Protein Domain: Transmembrane/Linker/Pore


Paralogue Variants mapped to KCNH2 residue 646

No paralogue variants have been mapped to residue 646 for KCNH2.



KCNH2YFTFSSLTSVGFGNVSPNTNSEKIFSICVM>L<IGSLMYASIFGNVSAIIQRLYSGTARYHTQ676
KCNH1YFTMTSLTSVGFGNIAPSTDIEKIFAVAIM>M<IGSLLYATIFGNVTTIFQQMYANTNRYHEM515
KCNH3YFALSSLTSVGFGNVSANTDTEKIFSICTM>L<IGALMHAVVFGNVTAIIQRMYARRFLYHSR517
KCNH4YFTLSSLTSVGFGNVCANTDAEKIFSICTM>L<IGALMHAVVFGNVTAIIQRMYSRRSLYHSR491
KCNH5YFTMTSLTTIGFGNIAPTTDVEKMFSVAMM>M<VGSLLYATIFGNVTTIFQQMYANTNRYHEM484
KCNH6YFTFSSLTSVGFGNVSPNTNSEKVFSICVM>L<IGSLMYASIFGNVSAIIQRLYSGTARYHTQ528
KCNH7YFTFSSLTSVGFGNVSPNTNSEKIFSICVM>L<IGSLMYASIFGNVSAIIQRLYSGTARYHMQ679
KCNH8YFTLSSLTSVGFGNVSANTDAEKIFSICTM>L<IGALMHALVFGNVTAIIQRMYSRWSLYHTR486
CNGA1YWSTLTLTTIG-ETPPPVRDSEYVFVVVDF>L<IGVLIFATIVGNIGSMISNMNAARAEFQAR413
CNGA2YWSTLTLTTIG-ETPPPVKDEEYLFVIFDF>L<IGVLIFATIVGNVGSMISNMNATRAEFQAK388
CNGA3YWSTLTLTTIG-ETPPPVKDEEYLFVVVDF>L<VGVLIFATIVGNVGSMISNMNASRAEFQAK416
CNGA4YFSTLILTTVG-DTPPPAREEEYLFMVGDF>L<LAVMGFATIMGSMSSVIYNMNTADAAFYPD282
CNGB1YFAVKTLITIG-GLPDPKTLFEIVFQLLNY>F<TGVFAFSVMIGQMRDVVGAATAGQTYYRSC896
CNGB3YWAVRTLITIG-GLPEPQTLFEIVFQLLNF>F<SGVFVFSSLIGQMRDVIGAATANQNYFRAC458
HCN1FKAMSHMLCIGYGAQAPVSMSDLWITMLSM>I<VGATCYAMFVGHATALIQSLDSSRRQYQEK410
HCN2FKAMSHMLCIGYGRQAPESMTDIWLTMLSM>I<VGATCYAMFIGHATALIQSLDSSRRQYQEK479
HCN3FKAMSHMLCIGYGQQAPVGMPDVWLTMLSM>I<VGATCYAMFIGHATALIQSLDSSRRQYQEK363
HCN4FKAMSHMLCIGYGRQAPVGMSDVWLTMLSM>I<VGATCYAMFIGHATALIQSLDSSRRQYQEK530
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.L646Pc.1937T>C Putative BenignSIFT:
Polyphen: