Paralogue Annotation for KCNH2 residue 841

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 841
Reference Amino Acid: V - Valine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 841

No paralogue variants have been mapped to residue 841 for KCNH2.



KCNH2P----GKSNGDVRALTYCDLHKIHRDDLLE>V<LDMYPEFSDHFWSSL--EIT-FNLRDTNM-867
KCNH1L----AQSCANVRALTYCDLHVIKRDALQK>V<LEFYTAFSHSFSRNL--ILT-YNLRKRIV-706
KCNH3V----VKANADVKGLTYCVLQCLQLAGLHD>S<LALYPEFAPRFSRGLRGELS-YNLGAGGG-709
KCNH4DPNFVLKTSADVKALTYCGLQQLSSRGLAE>V<LRLYPEYGAAFRAGLPRDLT-FNLRQGSD-693
KCNH5L----AHACANVRALTYCDLHIIKREALLK>V<LDFYTAFANSFSRNL--TLT-CNLRKRII-675
KCNH6P----GKSSADVRALTYCDLHKIQRADLLE>V<LDMYPAFAESFWSKL--EVT-FNLRDAAG-719
KCNH7P----GKSNADVRALTYCDLHKIQREDLLE>V<LDMYPEFSDHFLTNL--ELT-FNLRHESA-870
KCNH8V----IKTNADVKALTYCDLQCIILKGLFE>V<LDLYPEYAHKFVEDIQHDLT-YNLREGHE-678
CNGA1G----NRRTANIKSIGYSDLFCLSKDDLME>A<LTEYPDAKTMLEEKGKQILMKDGLLDLNI-613
CNGA2G----NRRTANIRSLGYSDLFCLSKDDLME>A<VTEYPDAKKVLEERGREILMKEGLLDENE-588
CNGA3G----NRRTANIRSIGYSDLFCLSKDDLME>A<LTEYPEAKKALEEKGRQILMKDNLIDEEL-616
CNGA4G----NRRTANIKSLGYSDLFCLSKEDLRE>V<LSEYPQAQTIMEEKGREILLKMNKLDVNA-482
CNGB1G----NRRTANVVAHGFTNLFILDKKDLNE>I<LVHYPESQKLLRKKARRMLRSNNKPK----1091
CNGB3G----NRRTANVVAHGFANLLTLDKKTLQE>I<LVHYPDSERILMKKARVLLKQKAKTA-EAT656
HCN1------RRTASVRADTYCRLYSLSVDNFNE>V<LEEYPMMRRAFETVAIDRLDRIGKKNSIL-601
HCN2------RRTASVRADTYCRLYSLSVDNFNE>V<LEEYPMMRRAFETVAIDRLDRIGKKNSIL-670
HCN3------RRTASVRADTYCRLYSLSVDHFNA>V<LEEFPMMRRAFETVAMDRLLRIGKKNSIL-554
HCN4------RRTASVRADTYCRLYSLSVDNFNE>V<LEEYPMMRRAFETVALDRLDRIGKKNSIL-721
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.V841Lc.2521G>C Inherited ArrhythmiaLQTSSIFT:
Polyphen:
ReportsInherited ArrhythmiaLQTS Vagal reflexes following an exercise stress test: a simple clinical tool for gene-specific risk stratification in the long QT syndrome. J Am Coll Cardiol. 2012 60(24):2515-24. doi: 10.1016/j.jacc.2012.08.1009. 23158531