Paralogue Annotation for KCNH2 residue 937

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 937
Reference Amino Acid: S - Serine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 937

No paralogue variants have been mapped to residue 937 for KCNH2.



KCNH2RAGAGPSSRGRPGG---P--WGESPSSGPS>S<-------PESSEDEGP---GRSSSPLRLVP957
KCNH1AAERGGRDLDDLDV---E--KGNVLTEHAS>A<-------NHSLVKASV---VTVRESPATPV798
KCNH3P-TVSPAPADEPSS---P--LLSPGCTSSS>S<AAKLLSPRRTAPRPRL---GGRGRPGRAGA790
KCNH4RPR-RPLLLPNLSP---A--RPR--GSLVS>L<LGEELPPFSALVSSPS---LSPSLSPALAG788
KCNH5GSTQGDPERNQLQV---E--SRSLQNGASI>T<-------GTSVVTVSQ---ITPIQTSLAYV768
KCNH6SQNSMG------AG---P--CAPG-HPDAA>P<-------PLSISDASG---LWPELLQEMPP804
KCNH7DSADTIRHYQSSKR---H--FEEKKSRSSS>F<-------ISSIDDEQK---PLFSGIVDSSP957
KCNH8EAVSLSPICTRGSS---S--RNKKVGSNKA>Y<LGLSLKQLASGT-VPF---HSPIRVSRSNS774
CNGA1KQRLTKVEKFLKP-----LIDTEFSSIEGP>G<---------AESGPID---S----------689
CNGA2KQRITVLETKMKQ-----NNEDDYLSDGMN>S<---------PELAAAD---E----------663
CNGA3KQRLSQLESQVKG-----GG-DKPLADGEV>P<G-------DATKTEDK---Q----------693
CNGA4AYRIERLEWQTREW---PMPEDLAEADDEG>E<---------PEEGTSK---DE---------562
CNGB1ELAALEAAAKQQEL---V--EQAKSSQDVK>G<E-------EGSAAPDQ-----------HTH1175
CNGB3KLKREQAAQKKENSEGGE--EEGKENEDKQ>K<E-------NEDKQKEN-----------EDK733
HCN1QMTTLNSTSSTTTP---T--SRMRTQSPPV>Y<T-------ATSLSHSNL-H--------S--680
HCN2GLFPPPPPPPQVTS---A--IATLQQAAAM>S<F-------CPQVARPLVGP-----------749
HCN3TGAQLSGKPVLWEP---L--VHAPLQAAAV>T<S-------NVAIALTHQRG--------P--630
HCN4ASATPTPTPVIWTP---L--IQAPLQAAAA>T<T-------SVAIALTHHPRLPAAIFRPPPG811
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.S937Nc.2810G>A Inherited ArrhythmiaLQTSSIFT: tolerated
Polyphen: possibly damaging
ReportsInherited ArrhythmiaLQTS Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test. Heart Rhythm. 2009 6(9):1297-303. 19716085