Paralogue Annotation for KCNH2 residue 965

Residue details

Gene: KCNH2
Reference Sequences: LRG: LRG_288, Ensembl variant: ENST00000262186 / ENSP00000262186
Amino Acid Position: 965
Reference Amino Acid: G - Glycine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNH2 residue 965

No paralogue variants have been mapped to residue 965 for KCNH2.



KCNH2ESSEDEGP---GRSSSPLRLVPFSSP-RPP>G<EPPGGEPLMEDC------------------977
KCNH1HSLVKASV---VTVRESPATPVSFQA-AST>S<GVPDHAKLQAPGS-----------------819
KCNH3RTAPRPRL---GGRGRPGRAGALKAE-AGP>S<APPRALEG----------------------806
KCNH4SALVSSPS---LSPSLSPALAGQGHS-ASP>H<GPPRCSAAWKPPQ-----------------809
KCNH5TSVVTVSQ---ITPIQTSLAYVKTSE-SLK>Q<NNRDAMELKPNGG-----------------789
KCNH6LSISDASG---LWPELLQEMPPRHSP-QSP>Q<EDPDCWPLKLGSR-----------------825
KCNH7SSIDDEQK---PLFSGIVDSSPGIGK-ASG>L<DFEETVPTSGRMH-----------------978
KCNH8ASGT-VPF---HSPIRVSRSNSPKTK-QEI>D<PPNHNKRKEKNLK-----------------795
CNGA1-AESGPID---S------------------>-<------------------------------689
CNGA2-PELAAAD---E------------------>-<------------------------------663
CNGA3DATKTEDK---Q------------------>-<------------------------------693
CNGA4-PEEGTSK---DE----------------->-<------------------------------562
CNGB1EGSAAPDQ-----------HTHPKEA---->-<------------------------------1179
CNGB3NEDKQKEN-----------EDKGKE----->-<------------------------------736
HCN1ATSLSHSNL-H--------S---------->-<------------------------------680
HCN2CPQVARPLVGP------------------->-<------------------------------749
HCN3NVAIALTHQRG--------P---------->-<------------------------------630
HCN4SVAIALTHHPRLPAAIFRPPPGSGLGNLGA>G<QTPRHLKRLQSLIPSALGSASPASSPSQVD850
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNH2

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.G965Rc.2893G>A Putative BenignSIFT: tolerated
Polyphen: benign
ReportsPutative Benign Genetic polymorphisms in KCNQ1, HERG, KCNE1 and KCNE2 genes in the Chinese, Malay and Indian populations of Singapore. Br J Clin Pharmacol. 2006 61(3):301-8. 16487223