Paralogue Annotation for KCNJ2 residue 8

Residue details

Gene: KCNJ2
Reference Sequences: LRG: LRG_328, Ensembl variant: ENST00000535240 / ENSP00000441848
Amino Acid Position: 8
Reference Amino Acid: R - Arginine
Protein Domain: N-terminus

Paralogue Variants mapped to KCNJ2 residue 8

No paralogue variants have been mapped to residue 8 for KCNJ2.

KCNJ2	-MGSVR-------------TN>R<YSIV--SSEEDGM--KLATMAVANGF-GNG	33
KCNJ1	MNASSR-------------NV>F<DTLIRVLTESMFK--HLRK------W-VVT	30
KCNJ3	MSALRRK---------FGDDY>Q<VVTT--SSSGS----GLQPQG--PGQ-D-P	33
KCNJ4	MHGHSR--------------->-<----------------------------NG	8
KCNJ5	MAGDSR--------NAMNQDM>E<IGVT--PWDPKKIPKQARDYV--PIATD-R	39
KCNJ6	MAKLTESMTNVLEGDSMDQDV>E<SPVA--IHQP-KLPKQARDDL--PRHIS-R	46
KCNJ8	MLARKS-----------IIPE>E<YVLA--RIAA---------------E-NLR	23
KCNJ9	--------------------M>A<QENA--AFSP-------------------G	11
KCNJ10	-MTSVA-------------KV>Y<YSQT--TQTES------------------R	18
KCNJ11	MLSRKG-----------IIPE>E<YVLT--RLA----------------E-DPA	22
KCNJ12	MTAASR-------------AN>P<YSIV--SSEEDGL--HLVTMSGANGF-GNG	34
KCNJ13	--------------------->-<------MDSSNCK--VIAP------L-L--	13
KCNJ14	-MGLARALR---RLSGALDSG>D<SRAG--DEEEAGP--GLCRNGWAPAP-VQS	43
KCNJ15	--MDAI-------------HI>G<MSST--PLVKH------------------T	17
KCNJ16	--MSYY-------------GS>S<YHII--NADAKYP-----------GY-PPE	23
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See full Alignment of Paralogues

Known Variants in KCNJ2

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.R8H	c.23G>A	Putative Benign		rs140090605	SIFT: deleterious Polyphen: benign
p.R8C	c.22C>T	Putative Benign			SIFT: deleterious Polyphen: possibly damaging