Paralogue Annotation for RYR1 residue 637

Residue details

Gene: RYR1
Reference Sequences: Ensembl variant: ENST00000359596 / ENSP00000352608
Amino Acid Position: 637
Reference Amino Acid: I - Isoleucine
Protein Domain:


Paralogue Variants mapped to RYR1 residue 637

No paralogue variants have been mapped to residue 637 for RYR1.



RYR1VCNGVAVRSNQDLITENLLPGRELLLQTNL>I<NYVTSIRPNIFVGRAEGTTQYSKWYFEVMV667
RYR2VCHGVAVRSNQHLICDNLLPGRDLLLQTRL>V<NHVSSMRPNIFLGVSEGSAQYKKWYYELMV679
RYR3LCNGVAVRANQNLICDNLLPRRNLLLQTRL>I<NDVTSIRPNIFLGVAEGSAQYKKWYFELII666
cons                              > <                              

See full Alignment of Paralogues


Known Variants in RYR1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.I637Vc.1909A>G Putative BenignSIFT: tolerated
Polyphen: benign