Paralogue Annotation for SCN5A residue 1115

Residue details

Gene: SCN5A
Reference Sequences: LRG: LRG_289, Ensembl variant: ENST00000333535 / ENSP00000328968
Amino Acid Position: 1115
Reference Amino Acid: W - Tryptophan
Protein Domain: Interdomain Linker II-III


Paralogue Variants mapped to SCN5A residue 1115

No paralogue variants have been mapped to residue 1115 for SCN5A.



SCN5AATASS------EA---------EASASQAD>W<RQQWKAEPQAPG----CGETPE--------1133
SCN1A------------------------------>-<-----------------KLNES--------1148
SCN2A------------------------------>-<-----------------KLN-A--------1137
SCN3A------------------------------>-<-----------------KLN-A--------1135
SCN4A------------------------------>-<-----------------PLY-D--------959
SCN7A------------------------------>-<-----------------KIK-Q--------868
SCN8A------------------------------>-<-----------------KLD-D--------1128
SCN9A------------------------------>-<-----------------RLN-R--------1110
SCN10A------------------------------>-<-----------------GVD-D--------1080
SCN11AQENKK------PT---------SQRVQSVE>I<DMFSEDEPHLTIQDPRKKSD-V--------987
CACNA1AQSPAKMGNSTDPGPMLAIPAMATNPQNAAS>R<RTPNNPGNPSNPGPP--KTP-ENSLIVTNP1150
CACNA1BEKEAEIVEADKEKELR-NHQPREPHCDLET>S<GTVTVGPMHTLPSTC--LQK-VEEQPEDAD1060
CACNA1C------------------------------>-<------------------------------
CACNA1D------------------------------>-<------------------------------
CACNA1ERVI-------S------QSEPDLSCITAN->-<------------TDK--ATT-ESTSVTVAI1074
CACNA1F------------------------------>-<------------------------------
CACNA1G------------------------------>-<------------------------------
CACNA1H------------------------------>-<------------------------------
CACNA1I------------------------------>-<------------------------------
CACNA1S------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in SCN5A

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.W1115Rc.3343T>C Putative BenignSIFT:
Polyphen: