Paralogue Annotation for SCN5A residue 1154

Residue details

Gene: SCN5A
Reference Sequences: LRG: LRG_289, Ensembl variant: ENST00000333535 / ENSP00000328968
Amino Acid Position: 1154
Reference Amino Acid: I - Isoleucine
Protein Domain: Interdomain Linker II-III


Paralogue Variants mapped to SCN5A residue 1154

No paralogue variants have been mapped to residue 1154 for SCN5A.



SCN5A----------DSCSEGSTADMTNTAELLEQ>I<PDLGQDVKDP------------------ED1166
SCN1A----------SSSSEGSTVDIGAPVE--EQ>P<VVEPEETLEP------------------EA1179
SCN2A----------TSSSEGSTVDIGAPAEG-EQ>P<EVEPEESLEP------------------EA1169
SCN3A----------TSSSEGSTVDVVLPREG-EQ>A<ETEPEEDLKP------------------EA1167
SCN4A----------GNSSVCSTADYKPPEEDPEE>Q<AEENPEGEQP------------------EE992
SCN7A----------SSSSECSTVDIAISEEE--E>M<----FYGGER------------------SK895
SCN8A----------TSSSEGSTIDIKPEVE--EV>P<VEQPEEYLDP------------------DA1159
SCN9A----------SSSSECSTVDNPLPGEG-EE>A<EAEPMNSDEP------------------EA1142
SCN10A----------TSSSEGSTVDCLDPEEILRK>I<PELADDLEEP------------------DD1113
SCN11A---------TSILSECSTIDLQDGFG--WL>P<--EMVPKKQP------------------ER1017
CACNA1ASGTQTNSAKTARKPDHTTVDIPPACPPPL->-<-------NHTVVQVNKNANPDPLPKKEEEK1202
CACNA1BNQRNVTRMGSQPPDPNTIVHIPVMLTGPL->-<-------GEATVVPSGNVD---LESQAEGK1109
CACNA1C--------------------------RPL->-<-------SEL----------H---------866
CACNA1D--------------------------RRI->-<-------SEL----------N---------872
CACNA1EPDVDP-------LVDSTVVHISNKTDG--->-<--------EASPLKEAEI----REDEEEVE1112
CACNA1F--------------------------ELL->-<-------QEV----------V---------837
CACNA1G--------------------------RAW->-<-------IRA----------R---------1243
CACNA1H--------------------------HKV->-<-------LEP----------Y---------1261
CACNA1I--------------------------RKM->-<-------IDV----------Y---------1137
CACNA1S--------------------------RPL->-<-------AEL----------Q---------765
cons                              > <                              

See full Alignment of Paralogues


Known Variants in SCN5A

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.I1154Nc.3461T>A Putative BenignSIFT: tolerated
Polyphen: benign