Paralogue Annotation for SCN5A residue 1515

Residue details

Gene: SCN5A
Reference Sequences: LRG: LRG_289, Ensembl variant: ENST00000333535 / ENSP00000328968
Amino Acid Position: 1515
Reference Amino Acid: N - Asparagine
Protein Domain: Interdomain Linker III-IV


Paralogue Variants mapped to SCN5A residue 1515

No paralogue variants have been mapped to residue 1515 for SCN5A.



SCN5AKK-L----G-SKKP--------QKPIPRPL>N<KYQGFIFDIVTKQAFDVTIMFLICLNMVTM1545
SCN1AKK-L----G-SKKP--------QKPIPRPG>N<KFQGMVFDFVTRQVFDISIMILICLNMVTM1558
SCN2AKK-L----G-SKKP--------QKPIPRPA>N<KFQGMVFDFVTKQVFDISIMILICLNMVTM1548
SCN3AKK-L----G-SKKP--------QKPIPRPA>N<KFQGMVFDFVTRQVFDISIMILICLNMVTM1543
SCN4AKK-L----G-SKKP--------QKPIPRPQ>N<KIQGMVYDLVTKQAFDITIMILICLNMVTM1370
SCN7AKK-L----M-YEDS--------QRPVPRPL>N<KLQGFIFDVVTSQAFNVIVMVLICFQAIAM1268
SCN8AKK-L----G-SKKP--------QKPIPRPL>N<KIQGIVFDFVTQQAFDIVIMMLICLNMVTM1539
SCN9AKK-L----G-SKKP--------QKPIPRPG>N<KIQGCIFDLVTNQAFDISIMVLICLNMVTM1521
SCN10AKK-L----G-SKKP--------QKPIPRPL>N<KFQGFVFDIVTRQAFDITIMVLICLNMITM1493
SCN11AKK-L----G-SKKP--------QKPIPRPL>N<KCQGLVFDIVTSQIFDIIIISLIILNMISM1383
CACNA1ADFAI------SAKP-------LTRHMPQNK>Q<SFQYRMWQFVVSPPFEYTIMAMIALNTIVL1583
CACNA1BDFAI------SAKP-------LTRYMPQNR>Q<SFQYKTWTFVVSPPFEYFIMAMIALNTVVL1489
CACNA1CEYAL------KARP-------LRRYIPK-->N<QHQYKVWYVVNSTYFEYLMFVLILLNTICL1236
CACNA1DEYAL------KARP-------LRRYIPK-->N<PYQYKFWYVVNSSPFEYMMFVLIMLNTLCL1242
CACNA1EDFAI------SAKP-------LTRYMPQNR>H<TFQYRVWHFVVSPSFEYTIMAMIALNTVVL1495
CACNA1FEYAL------KAQP-------LRRYIPK-->N<PHQYRVWATVNSAAFEYLMFLLILLNTVAL1207
CACNA1GDDVI-----ASGSSASAASEAQCKPYYSDY>S<RFRLLVHHLCTSHYLDLFITGVIGLNVVTM1628
CACNA1HRRRRSTFPSPEAQ---------RRPYYADY>S<PTRRSIHSLCTSHYLDLFITFIICVNVITM1634
CACNA1IKKRR------KAQ---------RLPYYATY>C<HTRLLIHSMCTSHYLDIFITFIICLNVVTM1504
CACNA1SQYAL------KARP-------LRCYIPK-->N<PYQYQVWYIVTSSYFEYLMFALIMLNTICL1135
cons                              > <                              

See full Alignment of Paralogues


Known Variants in SCN5A

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.N1515Sc.4544A>G Putative Benignrs373404919SIFT: deleterious
Polyphen: benign