No paralogue variants have been mapped to residue 1582 for SCN5A.
| SCN5A | QSPEKINILAKINLLFVAIFTGECIVKLAA>L<R-HYYFTNSWNIFDFVVVILSIVGTVLSDI | 1611 |
| SCN1A | QSEYVTTILSRINLVFIVLFTGECVLKLIS>L<R-HYYFTIGWNIFDFVVVILSIVGMFLAEL | 1624 |
| SCN2A | QSQEMTNILYWINLVFIVLFTGECVLKLIS>L<R-YYYFTIGWNIFDFVVVILSIVGMFLAEL | 1614 |
| SCN3A | QGKYMTLVLSRINLVFIVLFTGEFVLKLVS>L<R-HYYFTIGWNIFDFVVVILSIVGMFLAEM | 1609 |
| SCN4A | QSQLKVDILYNINMIFIIIFTGECVLKMLA>L<R-QYYFTVGWNIFDFVVVILSIVGLALSDL | 1436 |
| SCN7A | QSLQMSIALYWINSIFVMLYTMECILKLIA>F<R-CFYFTIAWNIFDFMVVIFSITGLCLPMT | 1334 |
| SCN8A | QSKQMENILYWINLVFVIFFTCECVLKMFA>L<R-HYYFTIGWNIFDFVVVILSIVGMFLADI | 1605 |
| SCN9A | QSQHMTEVLYWINVVFIILFTGECVLKLIS>L<R-HYYFTVGWNIFDFVVVIISIVGMFLADL | 1587 |
| SCN10A | QSEEKTKILGKINQFFVAVFTGECVMKMFA>L<R-QYYFTNGWNVFDFIVVVLSIASLIFSAI | 1559 |
| SCN11A | QPKAMKSILDHLNWVFVVIFTLECLIKIFA>L<R-QYYFTNGWNLFDCVVVLLSIVSTMISTL | 1449 |
| CACNA1A | ASVAYENALRVFNIVFTSLFSLECVLKVMA>F<GILNYFRDAWNIFDFVTVLGSITDILVTEF | 1650 |
| CACNA1B | APYEYELMLKCLNIVFTSMFSMECVLKIIA>F<GVLNYFRDAWNVFDFVTVLGSITDILVTEI | 1556 |
| CACNA1C | QSCLFKIAMNILNMLFTGLFTVEMILKLIA>F<KPKHYFCDAWNTFDALIVVGSIVDIAITEV | 1303 |
| CACNA1D | QSKMFNDAMDILNMVFTGVFTVEMVLKVIA>F<KPKGYFSDAWNTFDSLIVIGSIIDVALSEA | 1309 |
| CACNA1E | APCTYELALKYLNIAFTMVFSLECVLKVIA>F<GFLNYFRDTWNIFDFITVIGSITEIILTDS | 1562 |
| CACNA1F | QTAPFNYAMDILNMVFTGLFTIEMVLKIIA>F<KPKHYFTDAWNTFDALIVVGSIVDIAVTEV | 1274 |
| CACNA1G | QPQILDEALKICNYIFTVIFVLESVFKLVA>F<GFRRFFQDRWNQLDLAIVLLSIMGITLEEI | 1695 |
| CACNA1H | QPKSLDEALKYCNYVFTIVFVFEAALKLVA>F<GFRRFFKDRWNQLDLAIVLLSLMGITLEEI | 1701 |
| CACNA1I | QPTSLETALKYCNYMFTTVFVLEAVLKLVA>F<GLRRFFKDRWNQLDLAIVLLSVMGITLEEI | 1571 |
| CACNA1S | QSEQMNHISDILNVAFTIIFTLEMILKLMA>F<KARGYFGDPWNVFDFLIVIGSIIDVILSEI | 1202 |
| cons | > < |
| Protein | CDS | Disease Classification | Disease | dbSNP links | Effect Prediction |
|---|---|---|---|---|---|
| p.L1582P | c.4745T>C | Inherited Arrhythmia | BrS | rs199473275 | SIFT: deleterious Polyphen: probably damaging |
| Reports | Inherited Arrhythmia | BrS | Exercise-induced ECG changes in Brugada syndrome. Circ Arrhythm Electrophysiol. 2009 2(5):531-9. 19843921 | ||
| Inherited Arrhythmia | BrS | An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. Heart Rhythm. 2010 7(1):33-46. 20129283 | |||