Paralogue Annotation for SCN5A residue 659

Residue details

Gene: SCN5A
Reference Sequences: LRG: LRG_289, Ensembl variant: ENST00000333535 / ENSP00000328968
Amino Acid Position: 659
Reference Amino Acid: R - Arginine
Protein Domain: Interdomain Linker I-II


Paralogue Variants mapped to SCN5A residue 659

No paralogue variants have been mapped to residue 659 for SCN5A.



SCN5ATTTPSEEPGGPQMLTSQAPCVD-GFEEPGA>R<QR-A-LSAVSVLTSA----L-EELE-ESR-680
SCN1ANGTTTETEMRKRRSSSFHVSMD-FLEDPSQ>R<QR-A-MSIASILTNT----V-EELE-ESR-731
SCN2A-GTTTETEIRKRRSSSYHVSMD-LLEDPTS>R<QR-A-MSIASILTNT----M-EELE-ESR-722
SCN3A-GTTTETEVRKRRLSSYQISME-MLEDSSG>R<QR-A-VSIASILTNT----M-EELE-ESR-723
SCN4A-----------------------E---KGA>P<RQ-S-SSGDSGISDA----M-EELE-EAH-541
SCN7A---TIQIEMKKRSPISTDTSLD-VLEDATL>R<HK-------------------EELE-KSK-468
SCN8A-A-TTEVEIKKKGPGSLLVSMD-QLASYGR>K<DR-I-NSIMSVVTNTL---V-EELE-ESQ-716
SCN9A--TTNQIH-KKRRCSSYLLSED-MLNDPNL>R<QR-A-MSRASILTNT----V-EELE-ESR-696
SCN10AAVDVSAFD---AGQKKTFLSAE-YLDEPFR>A<QR-A-MSVVSIITSV----L-EELE-ESE-628
SCN11A---------KRLSQNLSLDHFD-EHGDPLQ>R<QR-A-LSAVSILTIT----M-KEQE-KSQ-540
CACNA1A--D----------LLNPEEAED-QLA---->D<IA-S-VG-----------------------450
CACNA1B--D----------LIHAEEGED-RFA---->D<LC-A-VG-----------------------446
CACNA1C--E----------SVNTENVAG-G-D---->I<EGEN-CG-----------------------490
CACNA1D--E----------SVNTENVSG-EGE---->N<RG-C-CGSLWCWWR-------RRGA-AKA-504
CACNA1E--E----------AMTRDSSDE-HCV---->D<IS-S-VG-----------------------439
CACNA1F--T----------RS-THSTSSHASL---->P<-A-SDTGSMTETQG-------DEDE-EEG-490
CACNA1GCLK----------ADSGACGPD-SCP---->Y<CA-R-AG-----AG-----EVELADREMP-686
CACNA1HSPP----------AGTLTCELK-SCP---->Y<CT-R-AL-----ED-P---EGELSGSESG-720
CACNA1I-------------------DPA-SCP---->C<CQ-H-ED-----GR-RPSGLGS---TDSGQ574
CACNA1S--E----------SLY-EI----------->-<---------------------------AG-403
cons                              > <                              

See full Alignment of Paralogues


Known Variants in SCN5A

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.R659Qc.1976G>A Putative BenignSIFT: deleterious
Polyphen: probably damaging
p.R659Wc.1975C>T Putative BenignSIFT:
Polyphen: